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Six Prognostic Factors ID'd for Invasive Disease After DCIS

THURSDAY, April 25, 2019 -- In a review published online April 25 in Cancer Epidemiology, Biomarkers & Prevention, six prognostic factors are identified that may predict invasive disease after a diagnosis of ductal carcinoma in situ (DCIS).

Lindy L. Visser, from the Netherlands Cancer Institute in Amsterdam, and colleagues conducted a systematic review with meta-analyses to summarize current knowledge on prognostic factors for invasive disease after DCIS diagnosis. The risk for invasive recurrence was assessed in eligible studies involving women primarily diagnosed and treated for DCIS and including at least 10 ipsilateral-invasive breast cancer events and one year of follow-up. The average effect size of the prognostic factors was assessed.

Forty studies met the inclusion criteria. In the meta-analyses, the researchers found six prognostic factors that were statistically significant: African-American race, premenopausal status, detection by palpation, involved margins, high histologic grade, and high p16 expression (pooled estimates: 1.43, 1.59, 1.84, 1.63, 1.36, and 1.51, respectively). Six prognostic factors that correlated with invasive recurrence were identified. The investigators note that other factors need confirmation in well-designed studies.

"Measurement and evaluation of prognostic factors have the potential to improve the clinical management of women diagnosed with DCIS," the authors write. "Nonetheless, studies assessing these factors should be of sufficient rigor to reach a high level of specificity and sensitivity."

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Posted: April 2019

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