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Second, Unrelated Cancers Strike 1 in 12 Cancer Patients

THURSDAY, July 7, 2016 -- A new study found that 8 percent of patients -- or one in 12 -- already diagnosed with one form of cancer end up developing a second type of unrelated cancer.

The second cancer was fatal in 55 percent of the cases, the study found.

"As clinicians, we can become so focused on surveilling our patients to see if a primary cancer recurs that we sometimes may not be aware that patients can be at risk of developing a second, unrelated cancer," said study author Dr. Karim Chamie, an assistant professor of urology at the David Geffen School of Medicine at University of California, Los Angeles.

Chamie added that the findings should encourage physicians to adjust the way they tackle follow-up care and monitoring among cancer patients.

The current study included more than 2 million people diagnosed with cancer. Patients in the study were initially diagnosed with cancers of the prostate, breast, lung, colon, rectum, bladder, uterus or kidney, or melanoma or non-Hodgkin lymphoma. Of those who developed a second cancer, only 13 percent died from their initial cancer, researchers said.

Chamie's team found that patients diagnosed with bladder cancer were the most at risk for developing a second cancer.

Thirty-four percent of bladder cancer patients were diagnosed with a second cancer during the 20-year study. Of those second cancers, 25 percent were lung cancer cases, the study found.

The study team suggested that this finding points to the need for annual screening with a CT scan of the lungs for bladder cancer patients.

"Lung cancer is a very common and extremely lethal disease, and the national screening trial found [in 2011] CT scans actually saved lives," Chamie explained in a school news release.

"We could make a significant improvement in cancer survivorship, for instance, if we monitored bladder cancer patients annually for second, unrelated lung cancers," he added.

People initially diagnosed with non-Hodgkin's lymphoma also faced a particularly high risk for a second cancer, the research team noted. The most common second cancers for these patients were lung, prostate or breast cancers.

The findings are in the July 5 issue of Cancer.

More information

There's more on second cancers at the American Cancer Society.

Posted: July 2016


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