High SARS-CoV-2 Genomic Load Tied to Worse Outcomes
WEDNESDAY, Nov. 4, 2020 -- For patients admitted to the hospital with COVID-19 pneumonia, high genomic load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with worse outcomes, according to research published online Oct. 29 in the Annals of the American Thoracic Society.
Ioannis M. Zacharioudakis, M.D., from the NYU School of Medicine in New York City, and colleagues examined the association between SARS-CoV-2 genomic load in nasopharyngeal samples and clinical outcomes among patients admitted to the hospital with COVID-19 pneumonia. The cycle threshold (Ct) value was used as a surrogate for viral load; Ct values were classified into genomic load based on tertiles: low, intermediate, and high.
The final analysis included 314 patients who presented to the emergency department. The researchers found that 34.1, 32.8, and 33.1 percent of patients were categorized into low, intermediate, and high SARS-CoV-2 genomic load categories. In a multivariate analysis, transplant history and duration of symptoms remained significantly associated with high genomic load (odds ratios, 5.36 and 0.93, respectively). Patients with high versus low genomic load had a significantly increased unadjusted risk for death and for reaching the composite outcome of death, intubation, or extracorporeal membrane oxygenation. Genomic load remained an independent risk factor for the composite outcome in the multivariable model (odds ratio, 1.59).
"Our study provides a justification for using patients' SARS-CoV-2 load at the time of hospital admission to assess their risk of adverse outcomes," Zacharioudakis said in a statement.
© 2021 HealthDay. All rights reserved.
Posted: November 2020
Further Support and Information on COVID-19
Read this next
WEDNESDAY, Jan. 27, 2021 -- Certain risk factors are associated with college students self-reporting a psychological impact of the COVID-19 pandemic, according to a study...
WEDNESDAY, Jan. 27, 2021 -- Retired doctors and nurses are being called to the front lines of the U.S. COVID-19 vaccination effort, the White House COVID-19 Response team...
WEDNESDAY, Jan. 27, 2021 -- For patients hospitalized with COVID-19, respiratory, physical, and psychological sequelae are common at four months after discharge, according to a...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.