Skip to Content

Rural, Urban Disparities Seen for New Liver Cancer Cases

TUESDAY, Nov. 24, 2020 -- Rates of hepatocellular carcinoma (HCC) have slowed in urban areas but continue to increase in rural areas, particularly among Black and Hispanic residents, according to a study presented at The Liver Meeting, the annual meeting of the American Association for the Study of Liver Diseases, held virtually from Nov. 13 to 16.

Christina Gainey, M.D., from the University of Southern California in Los Angeles, and colleagues used data from the North American Association of Central Cancer Registries to compare incidence trends for HCC over 20 years (1995 to 2016) and to understand incidence differences in rural versus urban settings.

The researchers identified 310,635 cases of HCC (85 percent urban and 15 percent rural). Age-adjusted incidence rates (AAIRs) were lower in rural areas (4.9/100,000) versus urban areas (6.9/100,000). However, average annual percentage change (AAPC) was higher in rural versus urban areas (5.7 versus 3.9 percent). The rise in urban incidence slowed in 2009, with an average annual increase of 5.3 percent before 2009 but only a 2.7 percent increase from 2009 to 2016. There was no similar slowing in rural areas. The highest increase in incidence over 20 years was among rural non-Hispanic Whites (AAPC, 5.7 percent). Among Blacks, those in urban areas had the highest single segment of growth between 1999 and 2009 (AAPC, 6.6 percent), while rates in rural Blacks continued to rise (AAPC, 5.4 percent). The only overall decline in incidence was seen among urban Asian/Pacific Islanders (AAPC, −1.0 percent). By 2016, rural Hispanics had the highest AAIR of all racial/ethnic groups (14.9/100,000).

"As nearly one in five Americans lives in a rural area, health disparities in this population represent a critical public health issue," Gainey said in a statement.

Two authors disclosed financial ties to Gilead Sciences and/or Roche-Genentech.

Press Release

More Information

© 2021 HealthDay. All rights reserved.

Posted: November 2020

Read this next

In Cirrhosis, Women Have Worse Frailty Scores Than Men

MONDAY, Jan. 4, 2021 -- Among patients with cirrhosis, women have worse frailty scores than men, which accounts for part of the gender gap in mortality while awaiting liver...

HFE Hemochromatosis May Up Risk for Liver Cancer in Men

FRIDAY, Dec. 11, 2020 -- Men with hemochromatosis HFE p.C282Y homozygosity have an increased risk for incident primary hepatic malignancy and death, according to a study published...

Viral Exposure Signature Predicts Hepatocellular Carcinoma

FRIDAY, July 10, 2020 -- A viral exposure signature can predict hepatocellular carcinoma (HCC) risk before clinical diagnosis among at-risk patients, according to a study...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.