Resting-State EEG Can Predict Sertraline Treatment Outcomes
MONDAY, Feb. 10, 2020 -- A latent-space machine learning algorithm tailored for resting-state electroencephalography (rsEEG) can predict treatment outcomes with sertraline in depression, according to a study published online Feb. 10 in Nature Biotechnology.
Wei Wu, Ph.D., from South China University of Technology in Guangzhou, and colleagues designed a latent-space machine learning algorithm tailored for rsEEG and applied it to data from an antidepressant treatment prediction study in depression to identify treatment-responsive neurobiological phenotype.
The researchers found that symptom change was predicted in a manner that was specific for sertraline versus placebo and generalizable across study sites and EEG equipment. The sertraline-predictive EEG signature generalized to a second depression sample; reduced EEG-predicted symptom improvement was seen using the sertraline-defined model for historically treatment-resistant patients compared with those showing partial response. In a third independent data set, two properties of the predictive signature were examined: convergent validation and neurobiological significance. In this sample, the rsEEG-derived outcome predictions indexed prefrontal neural responsivity, as measured by concurrent transcranial magnetic stimulation (TMS). The smaller the rsEEG-predicted symptom improvement with sertraline, the better the response to TMS treatment over the right dorsolateral prefrontal cortex with concurrent psychotherapy in a fourth depression treatment data set.
"These findings ground in individual-level neurobiology a treatment-responsive phenotype obscured within the broader clinical diagnosis of depression and its associated biological heterogeneity, and lay a path towards machine learning-driven personalized approaches to treatment in depression," the authors write.
Several authors disclosed financial ties to the biopharmaceutical industry.
© 2020 HealthDay. All rights reserved.
Posted: February 2020
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
- Monthly Update Archive
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.