Skip to Content

Relugolix Combo Therapy Beneficial for Fibroid-Related Menorrhagia

THURSDAY, Feb. 18, 2021 -- For patients with uterine fibroids, once-daily relugolix combination therapy results in significantly reduced menstrual bleeding compared with placebo, according to a study published in the Feb. 18 issue of the New England Journal of Medicine.

Ayman Al-Hendy, M.D., Ph.D., from the University of Chicago, and colleagues conducted two replicate international, double-blind, 24-week, phase 3 trials involving women with fibroid-associated heavy menstrual bleeding (388 women in trial L1 and 382 in trial L2). Participants were randomly assigned to receive once-daily placebo, relugolix combination therapy (relugolix, estradiol, and norethindrone acetate), or delayed relugolix combination therapy (relugolix monotherapy followed by relugolix combination therapy each for 12 weeks). The primary efficacy end point was the percentage of participants with response (volume of menstrual blood loss <80 mL; ≥50 percent reduction in volume from baseline).

The researchers found that 73 and 71 percent of women in the relugolix combination therapy group in L1 and L2, respectively, had a response, compared with 19 and 15 percent, respectively, in the placebo group. In six of seven key secondary end points, including measures of menstrual blood loss and pain, but not fibroid volume, significant improvements were seen in both relugolix combination groups compared with the placebo group. A similar incidence of adverse events was seen with relugolix combination therapy and placebo.

"This combination therapy is especially a great option for this younger population who want to preserve their fertility," Al-Hendy said in a statement.

The study was funded by Myovant Sciences, the manufacturer of relugolix.

Abstract/Full Text (subscription or payment may be required)

© 2021 HealthDay. All rights reserved.

Read this next

Irregular, Long Menstrual Cycles Linked to Premature Mortality

THURSDAY, Oct. 1, 2020 -- Irregular and long menstrual cycles throughout the life course are associated with an increased risk for premature mortality, according to a study...

Fibroid-Related QOL Better With Myomectomy for Uterine Fibroids

THURSDAY, July 30, 2020 -- For women with symptomatic uterine fibroids, fibroid-related quality of life at two years is better for those undergoing myomectomy than those...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.