Skip to Content

Rates of Acute Allergic Reactions to COVID-19 Vaccines Extremely Low

THURSDAY, March 11, 2021 -- Severe reactions consistent with anaphylaxis have occurred among 2.47 per 10,000 health care workers receiving COVID-19 vaccinations, according to a research letter published online March 8 in the Journal of the American Medical Association.

Kimberly G. Blumenthal, M.D., from The Mongan Institute at Massachusetts General Hospital in Boston, and colleagues analyzed data from Massachusetts General Brigham employees who received their first dose of an mRNA COVID-19 vaccine (Dec. 16, 2020, to Feb. 12, 2021, with follow-up through Feb. 18, 2021) to assess acute allergic reactions.

Based on 52,805 employees who completed a symptom survey, the researchers report that 2.1 percent of employees had an acute allergic reaction. Reactions were more frequently reported with the Moderna vaccine versus the Pfizer-BioNTech vaccine (2.20 versus 1.95 percent). Anaphylaxis was confirmed in 16 employees (0.025 percent), including seven cases with the Pfizer-BioNTech vaccine (0.027 percent) and nine cases with the Moderna vaccine (0.023 percent). The mean age among individuals with anaphylaxis was 41 years, with the majority being female (15 patients; 94 percent). Ten individuals with anaphylaxis (63 percent) had a prior allergy history and five (31 percent) had an anaphylaxis history. Mean time to onset of anaphylaxis was 17 minutes. All anaphylaxis patients recovered, with one admitted to intensive care and nine (56 percent) receiving intramuscular epinephrine. Three individuals with prior anaphylaxis history did not seek care.

"The incidence rate of confirmed anaphylaxis in this study is larger than that reported by the Centers for Disease Control and Prevention," the authors write. "However, the overall risk of anaphylaxis to an mRNA COVID-19 vaccine remains extremely low."

Abstract/Full Text

© 2021 HealthDay. All rights reserved.

Read this next

Risk for Subsequent SARS-CoV-2 Infection Lower With Seropositivity

MONDAY, April 19, 2021 -- Among healthy, young adults, those who are seropositive rather than seronegative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have a...

Half of American Adults Have Received at Least One COVID-19 Vaccine Shot

MONDAY, April 19, 2021 -- Half of all Americans aged 18 years or older have now gotten at least one shot in the arm of a COVID-19 vaccine, the U.S. Centers for Disease Control and...

AAN: Stroke Occurs in 2.2 Percent of Patients Admitted to ICU With COVID-19

MONDAY, April 19, 2021 -- For patients with COVID-19 admitted to the intensive care unit (ICU), stroke is not a common complication, according to a study presented at the annual...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.