Skip to Content

Previously Infected May Only Need Single Dose of COVID-19 Vaccine

MONDAY, April 5, 2021 -- Individuals previously infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have antibody responses to one dose of the BNT162b2 (Pfizer-BioNTech) mRNA vaccine that are comparable to those of infection-naive individuals receiving two doses, according to a study published online April 1 in Nature Medicine.

Joseph E. Ebinger, M.D., from the Cedars-Sinai Medical Center in Los Angeles, and colleagues enrolled 1,090 health care workers from an academic medical center in Southern California who received BNT162b2 mRNA vaccine. Antibody levels were measured at three time points: before or up to three days after dose one, within seven to 21 days after dose one, and within seven to 21 days after dose two.

The researcher found that for individuals with prior SARS-CoV-2 infection (35 individuals), spike-specific immunoglobulin G antibody levels and angiotensin-converting enzyme 2 antibody binding inhibition responses elicited by a single vaccine dose were similar to those seen after two doses of vaccine in 228 individuals without prior infection. Postvaccine symptoms were experienced more often by individuals with previous SARS-CoV-2 infection than infection-naive individuals after dose one (36.8 versus 25.0 percent), but there was no difference between the groups in postvaccine symptoms after dose two (51.3 versus 58.7 percent).

"It appears that a single booster dose given to previously infected individuals offers the same benefit as two doses given to people without prior infection," a coauthor said in a statement.

Abstract/Full Text

© 2021 HealthDay. All rights reserved.

Read this next

Risk for Subsequent SARS-CoV-2 Infection Lower With Seropositivity

MONDAY, April 19, 2021 -- Among healthy, young adults, those who are seropositive rather than seronegative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have a...

Half of American Adults Have Received at Least One COVID-19 Vaccine Shot

MONDAY, April 19, 2021 -- Half of all Americans aged 18 years or older have now gotten at least one shot in the arm of a COVID-19 vaccine, the U.S. Centers for Disease Control and...

AAN: Stroke Occurs in 2.2 Percent of Patients Admitted to ICU With COVID-19

MONDAY, April 19, 2021 -- For patients with COVID-19 admitted to the intensive care unit (ICU), stroke is not a common complication, according to a study presented at the annual...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.