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Polycystic Ovary Syndrome Tied to Risk of Mental Health Issues

TUESDAY, April 10, 2018 -- Polycystic ovary syndrome (PCOS) is associated with higher risk of psychiatric conditions, according to a study published online April 10 in the Journal of Clinical Endocrinology & Metabolism.

Thomas R. Berni, from Cardiff Medicentre in the United Kingdom, and colleagues evaluated the association between PCOS and psychiatric outcomes, as well as whether rates of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are higher in children of mothers with PCOS. Identified patients (16,986) were matched (1:1) to controls based on by age, body mass index, and primary care practice (16,938 participants; control set 1) or by prior mental health status (16,355 participants; control set 2).

The researchers found that, baseline prevalence was significantly higher for patients versus control set 1 for depression (23.1 versus 19.3 percent), anxiety (11.5 versus 9.3 percent), and bipolar disorder (3.2 versus 1.5 percent) (P < 0.001). The hazard ratios for depression, anxiety, and bipolar disorder were 1.26 (95 percent confidence interval [CI], 1.19 to 1.32), 1.20 (95 percent CI, 1.11 to 1.29), and 1.21 (95 percent CI, 1.03 to 1.42) for set 1, and 1.38 (95 percent CI, 1.30 to 1.45), 1.39 (95 percent CI, 1.29 to 1.51), and 1.44 (95 percent CI, 1.21 to 1.71) for set 2. For ASD and ADHD in children the odds ratios were 1.54 (95 percent CI, 1.12 to 2.11) and 1.64 (95 percent CI, 1.16 to 2.33) for set 1, and 1.76 (95 percent CI, 1.27 to 2.46) and 1.34 (95 percent CI, 0.96 to 1.89) for set 2.

"PCOS is associated with psychiatric morbidity and increased risk of ADHD and ASD in their children," the authors write. "Screening for mental health disorders should be considered during assessment."

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Posted: April 2018

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