Platinum Therapy May Up Survival in Pancreatic Cancer With DNA Repair Defects
TUESDAY, May 26, 2020 -- For patients with advanced-stage pancreatic ductal adenocarcinoma (PDAC), those with homologous recombination deficiency (HRD) have improved survival with first-line (1L) platinum treatment, according to a study published online May 22 in Clinical Cancer Research.
Wungki Park, M.D., from Memorial Sloan Kettering Cancer Center in New York City, and colleagues examined progression-free survival (PFS) and overall survival (OS) in advanced-stage PDAC. Homologous recombination gene mutations (HRm) were assessed in various genes and HRm status was grouped as germline versus somatic; core (BRCAs and PALB2) versus noncore; and monoallelic versus biallelic.
The researchers found that 50 of 262 patients (19 percent) had HRD (15 percent germline and 4 percent somatic). Due to lack of difference in genomic instability and outcomes, the groups were analyzed together. Patients were followed for a median of 21.9 months. The median OS was 15.5 months and median PFS was seven months. Improved PFS was seen for patients with HRD versus no HRD when treated with 1L platinum (hazard ratio, 0.44), but not with 1L-nonplatinum. HRD patients had improved OS regardless of their firstline treatment in a multivariable analysis; however, most had platinum exposure during their course. Higher genomic instability was seen with biallelic HRm and core HRm (11 and 12 percent, respectively), which translated to improved PFS on 1L-platinum versus 1L-nonplatinum.
"HR deficiency defined by pathogenic mutation of core HR genes and loss of both copies of either core or noncore HR genes confers the greatest platinum sensitivity," Park said in a statement.
Several authors disclosed financial ties to the biopharmaceutical industry.
© 2021 HealthDay. All rights reserved.
Posted: May 2020
Read this next
TUESDAY, Feb. 2, 2021 -- Perioperative chemotherapy for resectable pancreatic cancer is safe and effective, but it did not improve overall survival (OS) compared with historical...
FRIDAY, Jan. 22, 2021 -- Opioid use seems to contribute to the increasing incidence of pancreatic cancer (PC) in the United States, according to a study published online Jan. 6 in...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.