Oral Contraceptives Protect Against Ovarian, Endometrial Cancer
Torgny Karlsson, Ph.D., from Uppsala University in Sweden, and colleagues conducted an observational study involving 256,661 women from the U.K. Biobank, born between 1939 and 1970, to clarify the time-dependent effects between long-term oral contraceptive use and cancer risk. The cumulative risk for cancer over the timespan of the study and instantaneous risk were measured by the odds ratio (OR) and hazard ratio (HR), respectively.
The researchers found that compared with never users, ever users had lower odds of ovarian cancer and endometrial cancer (ORs, 0.72 and 0.68, respectively); the association was stronger with longer use. When limiting follow-up to 55 years of age, increased odds of breast cancer were seen (OR, 1.10); but this finding was not seen for the full timespan. A higher HR for breast cancer was seen in former users immediately (no more than two years) after discontinued oral contraceptive use (HR, 1.55), while for ovarian and endometrial cancer, the protective effect remained significant up to 35 years after last use of oral contraceptives.
"It was clear that women who had used oral contraceptive pills had a much lower risk of developing both ovarian and endometrial cancer," a coauthor said in a statement. "A decreased risk was still detected up to 30 to 35 years after discontinuation."
© 2021 HealthDay. All rights reserved.
Posted: December 2020
Read this next
FRIDAY, Jan. 22, 2021 -- There was a significant decrease in the number of patients undergoing screening tests for cancer and in the number of resulting diagnoses of cancerous and...
TUESDAY, Jan. 19, 2021 -- Experience during the COVID-19 pandemic shows that virtual care at a high-volume cancer center is feasible, according to a study published online Jan. 7...
TUESDAY, Jan. 19, 2021 -- During 1999 to 2018, there was a decrease in the rate of cancer-related suicide, according to a study published online Jan. 19 in the Journal of the...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.