Obesity Linked to Adverse Events in Children With Leukemia
WEDNESDAY, Feb. 13, 2019 -- For children with acute lymphoblastic leukemia (ALL), obesity is associated with an increased risk for adverse events during premaintenance chemotherapy, according to a study published in the February issue of Pediatric Blood & Cancer.
Chelsea K. Meenan, from the University of Pittsburgh, and colleagues retrospectively evaluated 155 pediatric ALL patients diagnosed at a single institution between 2006 and 2012 for adverse events. The authors compared the proportions of obese versus nonobese patients experiencing adverse events.
The researchers found that in univariate analyses, treatment-requiring hypertension (17.5 versus 6.1 percent; odds ratio, 3.27) and insulin-requiring hyperglycemia (25.0 versus 11.3 percent; odds ratio, 2.62) occurred significantly more frequently in obese patients. The incidence rates for recurrent admission-requiring infections (incidence rate ratio, 1.64) and recurrent febrile neutropenia admissions (incidence rate ratio, 1.53) were greater for obese patients. Obesity was a risk factor for treatment-requiring hypertension, insulin-requiring hyperglycemia, and febrile neutropenia admission after accounting for combined age and National Cancer Institute risk status (odds ratios, 3.90, 3.92, and 2.92, respectively).
"Obese children with ALL represent a group of patients at risk for poor outcomes due to treatment-related morbidity," the authors write. "Early management of these adverse events and surveillance initiated at diagnosis may mitigate risk in this distinct population of patients."
© 2020 HealthDay. All rights reserved.
Posted: February 2019
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
- Monthly Update Archive
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.