Skip to Content

Noncalcified Coronary Plaque Up for People Living With HIV

FRIDAY, April 23, 2021 -- People living with HIV (PLWH) without known cardiovascular disease have an increased prevalence and volume of noncalcified coronary plaque, as measured by coronary computed tomography (CT) angiography, compared with healthy volunteers without HIV, according to a study published online April 20 in Radiology.

Irina Boldéanu, from the University of Montreal Hospital, and colleagues conducted a prospective study to measure CT characteristics of coronary plaque in PLWH without known cardiovascular disease (181 participants) and healthy volunteers without HIV (84 participants). The prevalence, frequency, and volume of calcified, mixed, and noncalcified plaque were measured using coronary CT angiography, which was performed in 155 PLWH and 78 healthy volunteers.

The researchers observed no difference in the median 10-year Framingham risk score for PLWH and healthy volunteers or in the coronary artery calcium score or overall plaque prevalence after adjustment for cardiovascular risk. PLWH had a higher noncalcified plaque prevalence (prevalence ratio, 2.5) and volume (odds ratio, 2.8). In PLWH, calcified plaque prevalence was reduced (odds ratio, 0.6). A higher volume of overall and mixed plaque was seen in association with treatment with protease inhibitors (odds ratios, 1.8 and 1.6, respectively).

"Our study shows that noncalcified coronary plaque is increased in people living with HIV," a coauthor said in a statement. "And noncalcified plaque has previously been shown to be associated with worse cardiovascular outcomes than calcified or mixed plaques."

Several authors disclosed financial ties to the biopharmaceutical and medical technology industry.

Abstract/Full Text

Editorial (subscription or payment may be required)

© 2021 HealthDay. All rights reserved.

Read this next

ART Ups Life Expectancy for HIV+ in Latin America, Caribbean

FRIDAY, April 30, 2021 -- Life expectancy among people with HIV receiving antiretroviral therapy (ART) has significantly improved in Latin America and the Caribbean, according to...

42 Percent of Transgender Women With Valid HIV Test Are HIV+

MONDAY, April 19, 2021 -- Forty-two percent of transgender women with a valid HIV test result have a positive result, with considerable regional and ethnic/racial variation,...

One-Fourth of HIV Patients Report Experiencing Intimate Partner Violence

FRIDAY, April 16, 2021 -- One in four people with HIV experience intimate partner violence, according to a study published online March 31 in the American Journal of Preventive...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.