Skip to Content

No Obvious Safety Signals ID'd for mRNA COVID-19 Vaccine in Pregnancy

THURSDAY, April 22, 2021 -- Preliminary findings indicate no obvious safety signals for pregnant women who receive mRNA COVID-19 vaccines, according to a study published online April 21 in the New England Journal of Medicine.

Tom T. Shimabukuro, M.D., from the U.S. Centers for Disease Control and Prevention in Atlanta, and colleagues used data from the "v-safe after vaccination health checker" surveillance system, the v-safe pregnancy register, and the Vaccine Adverse Event Reporting System (VAERS) to characterize the safety of mRNA COVID-19 vaccines in pregnant persons.

The researchers identified 35,691 pregnant v-safe participants aged 16 to 54 years. Compared with nonpregnant women, pregnant persons more often reported injection-site pain but less frequently reported headache, myalgia, chills, and fever. Overall, 827 of the 3,958 participants enrolled in the v-safe pregnancy registry had a completed pregnancy, of which 13.9 and 86.1 percent resulted in a pregnancy loss and a live birth, respectively. Adverse neonatal outcomes included preterm birth and small for gestational age (9.4 and 3.2 percent, respectively); there were no reports of neonatal deaths. Calculated proportions of adverse pregnancy and neonatal outcomes in persons vaccinated against COVID-19 with a completed pregnancy were similar to incidences in studies involving pregnant women conducted before the pandemic, although these proportions were not directly comparable. Spontaneous abortion was the most frequently reported event among the 221 pregnancy-related adverse events reported to the VAERS (46 cases).

"The present data can help inform decision making about vaccination by pregnant persons and their health care providers," the authors write.

One author disclosed financial ties to the pharmaceutical industry, including companies that have developed COVID-19 vaccines.

Abstract/Full Text

© 2021 HealthDay. All rights reserved.

Read this next

New Heart Failure Diagnosed in Hospitalized COVID-19 Patients

FRIDAY, May 14, 2021 -- Patients hospitalized with COVID-19 may be at risk for developing new heart failure, according to a research letter published in the May 4 issue of the...

Many Adults Unprotected Against Vaccine-Preventable Disease

FRIDAY, May 14, 2021 -- Many U.S. adults remain unprotected against vaccine-preventable diseases, according to research published in the May 14 issue of the U.S. Centers for...

CDC: COVID-19 Vaccine Can Be Given Along With Other Shots

THURSDAY, May 13, 2021 -- The U.S. Centers for Disease Control and Prevention said Wednesday that COVID-19 vaccines can be given along with other childhood shots, CNN reported...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.