No Link Found for Exposure to Epidural Labor Analgesia and Autism
TUESDAY, April 20, 2021 -- Exposure to epidural labor analgesia (ELA) is not associated with offspring risk for autism spectrum disorder (ASD), according to a study published online April 19 in JAMA Pediatrics.
Elizabeth Wall-Wieler, Ph.D., from the University of Manitoba in Winnipeg, Canada, and colleagues conducted a longitudinal cohort study of vaginal deliveries of singleton live infants born from 2005 to 2016 to examine the correlation between ELA and offspring risk for ASD. Data were included for 123,175 offspring, of whom 38.2 percent were exposed to ELA.
The researchers found that 2.1 percent of those exposed to ELA and 1.7 percent of unexposed offspring were diagnosed with ASD during the follow-up period (hazard ratio, 1.25; 95 percent confidence interval, 1.15 to 1.36). ELA was not associated with an offspring risk for ASD after adjustment for maternal sociodemographic, prepregnancy, pregnancy, and perinatal covariates (inverse probability of treatment-weighted hazard ratio, 1.08; 95 percent confidence interval, 0.97 to 1.20). ELA was not associated with ASD in the within-siblings design adjusting for baseline covariates (inverse probability of treatment-weighted hazard ratio, 0.97; 95 percent confidence interval, 0.78 to 1.22).
"This finding is of clinical importance in the context of pregnant women and their obstetric and anesthesia care professionals who are considering ELA during labor," the authors write.
One author disclosed financial ties to the pharmaceutical industry.
© 2021 HealthDay. All rights reserved.
Posted: April 2021
Read this next
The annual meeting of the American College of Obstetricians and Gynecologists was held virtually this year from April 30 to May 2 and attracted participants from around the world,...
WEDNESDAY, May 12, 2021 -- Women receiving the COVID-19 vaccine in their third trimester of pregnancy generate a strong immune response and pass protective antibodies through...
MONDAY, May 10, 2021 -- The rate of in-hospital mortality is lower for pregnant versus nonpregnant women hospitalized with COVID-19 and viral pneumonia, according to a research...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.