New Mammogram-Based Measures Improve Breast Cancer Prediction
WEDNESDAY, Dec. 30, 2020 -- New mammogram-based risk measures based on brightness (Cirrocumulus) and texture (Cirrus) improve breast cancer risk prediction beyond an established measure of mammographic density (Cumulus), according to a study recently published in the International Journal of Cancer.
Tuong L. Nguyen, Ph.D., from the University of Melbourne in Australia, and colleagues examined risk prediction with Cirrocumulus and Cirrus fitted together and with Cumulus using data from three studies consisting of 168 interval cases and 498 matched controls; 422 screen-detected cases and 1,197 matched controls; and 354 younger-diagnosis cases and 944 controls frequency-matched for age at mammogram. Measure-specific risk gradients were estimated as the change in odds per standard deviation of controls after adjustment for age and body mass index (OPERA); the area under the receiver operating characteristic curve (AUC) was also calculated.
The researchers found that for interval, screen-detected, and younger-diagnosis cancer risks, the best-fitting models involved Cumulus and Cirrus (OPERAs, 1.81 and 1.72, respectively), Cirrus and Cirrocumulus (OPERAs, 1.49 and 1.16, respectively), and Cirrus and Cirrocumulus (OPERAs, 1.70 and 1.46, respectively), with corresponding AUCs of 0.73, 0.63, and 0.72.
"Our new measures appear to be more strongly correlated with such causal factors than conventional mammographic density," the authors write. "Our findings also demonstrate the potential for much improved and more etiologically relevant breast cancer risk prediction, by discovering new ways of extracting information on breast cancer risk from a mammogram."
One author disclosed financial ties to Genetic Technologies.
© 2021 HealthDay. All rights reserved.
Posted: December 2020
Read this next
WEDNESDAY, Jan. 27, 2021 -- Promising new data on two antibody cocktails suggest these therapies can keep COVID-19 patients out of the hospital and even prevent illness altogether...
WEDNESDAY, Jan. 27, 2021 -- Aspirin use may improve survival for bladder and breast cancer, according to a study published online Jan. 15 in JAMA Network Open. Holli A....
WEDNESDAY, Jan. 27, 2021 -- Less than half of U.S. adults see a connection between systemic racism and poorer health outcomes, according to a report released Jan. 13 by the RAND...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.