Mortality Up for Male Recipients of Blood From Ever-Pregnant
TUESDAY, Oct. 17, 2017 -- For males, receipt of a red blood cell transfusion from an ever-pregnant female is associated with increased rate of all-cause mortality compared with a male donor, according to a study published online Oct. 17 in the Journal of the American Medical Association.
Camila Caram-Deelder, from Sanquin Research in the Netherlands, and colleagues examined the correlation between mortality and exposure to transfusions from ever-pregnant or never-pregnant female donors in a retrospective cohort study involving 31,118 first-time transfusion recipients.
The researchers found that mortality was 13 percent in the cohort. All-cause mortality rates for male recipients of red blood cell transfusions from an ever-pregnant female donor versus a male donor were 101 versus 80 deaths per 1,000 person-years (time-dependent per-transfusion hazard ratio [HR] for death, 1.13; 95 percent confidence interval [CI], 1.01 to 1.26). Mortality rates were 78 versus 80 deaths per 1,000 person-years for male recipients of transfusion from a never-pregnant female donor versus a male donor (HR, 0.93; 95 percent CI, 0.81 to 1.06). For female recipients of red blood cell transfusion, mortality rates were 74 versus 62 per 1,000 person-years for an ever-pregnant female versus a male donor (HR, 0.99; 95 percent CI, 0.87 to 1.13) and 74 versus 62 per 1,000 person-years for a never-pregnant female versus a male donor (HR, 1.01; 95 percent CI, 0.88 to 1.15).
"Further research is needed to replicate these findings, determine their clinical significance, and identify the underlying mechanism," the authors write.
One author disclosed financial ties to the pharmaceutical industry.
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Posted: October 2017