Model Can Aid Assessment of Multiple Pulmonary Nodules
THURSDAY, Feb. 25, 2021 -- A machine learning-based model has been developed and validated for predicting malignancy in multiple pulmonary nodules (MPNs), according to a study published online Feb. 24 in Clinical Cancer Research.
Kezhong Chen, M.D., from the Peking University People's Hospital in Beijing, and colleagues developed and validated a machine learning-based model to estimate the malignant probability of MPNs. Clinicoradiologic variables of 1,739 nodules from 520 patients with MPNs were used to predict malignancy with a boosted ensemble algorithm. Tenfold cross-validation was used to train the model (PKU-M model), which was then validated and compared with solitary pulmonary nodule models, clinicians, and a computer-aided diagnosis (CADx) system.
The researchers found that in the development cohort, the PKU-M model showed excellent discrimination (area under the curve [AUC], 0.909) and calibration (Brier score, 0.122). In external validation with 583 nodules, the AUC of the PKU-M model was 0.890, which was higher than those of the Brock model, PKU model, Mayo model, and VA model (AUCs, 0.806, 0.780, 0.739, and 0.682, respectively). The AUC of the PKU-M model (0.871) was higher than that of three thoracic surgeons (0.790, 0.741, and 0.727), a radiologist (0.748), and the CADx system (0.757) in prospective comparisons including 200 nodules. The model outperformed clinicians with increases of 14.3 and 7.8 percent in sensitivity and specificity, respectively.
"This first cancer prediction model specifically for MPNs demonstrated solid performance as a convenient reference to help decision-making," the authors write.
One author disclosed ties to Johnson & Johnson.
© 2021 HealthDay. All rights reserved.
Posted: February 2021
Read this next
TUESDAY, April 20, 2021 -- For older persons who are medically unwell and referred for a hospital admission, admission avoidance hospital at home (HAH) with comprehensive...
TUESDAY, April 20, 2021 -- A machine learning algorithm can use data from brain magnetic resonance imaging (MRI) to identify subtypes of multiple sclerosis (MS), according to a...
MONDAY, April 19, 2021 -- The official global COVID-19 death toll surpassed 3 million this weekend, according to Johns Hopkins University data. But the actual number of people...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.