Meds for Enlarged Prostate Tied to Heart Failure Risk
WEDNESDAY, March 17, 2021 -- Medications used for enlarged prostate are associated with a small, but significant, increase in developing heart failure, according to a study published online Feb. 22 in The Journal of Urology.
Avril Lusty, M.D., from Queen's University in Kingston, Ontario, Canada, and colleagues used administrative databases to identify 175,201 men older than 66 years with a diagnosis of benign prostatic hyperplasia (BPH) between 2005 and 2015. The primary outcome of new cardiac failure was compared for men with 5-alpha reductase inhibitor (5ARI) exposure and/or alpha-blocker (α-blocker) exposure.
The researchers identified 8,339 men exposed to 5ARI, 55,383 exposed to α-blockers, and 41,491 using combination therapy. There was a higher risk observed for cardiac failure among men treated with 5ARI and α-blocker, alone or in combination, versus men with no medication use. The risk for cardiac failure was highest for α-blockers alone (hazard ratio [HR], 1.22; 95 percent confidence interval [CI], 1.18 to 1.26), intermediate for combination α-blockers/5ARIs (HR, 1.16; 95 percent CI, 1.12 to 1.21), and lowest for 5ARI alone (HR, 1.09; 95 percent CI, 1.02 to 1.17). The risk for cardiac failure was higher for nonselective α-blockers than selective α-blockers (HR, 1.08; 95 percent CI, 1.00 to 1.17).
"This is an important finding, given that BPH is so common among older men, and that these medications are so widely used," a coauthor said in a statement.
© 2021 HealthDay. All rights reserved.
Posted: March 2021
Read this next
FRIDAY, March 5, 2021 -- Residents in rural counties have higher age-adjusted mortality rates (AAMRs) for heart failure-related death compared with urban adults, according to a...
FRIDAY, March 5, 2021 -- Among heart failure patients, hospital readmission is frequent and often occurs in the early postdischarge period, according to a study published online...
THURSDAY, Feb. 18, 2021 -- Users of terazosin, doxazosin, or alfuzosin are at lower risk for developing Parkinson disease (PD) compared with users of tamsulosin, according to a...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.