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Low-Carb Diet Does Not Up Risk for Primary Open-Angle Glaucoma

FRIDAY, July 24, 2020 -- Low-carbohydrate diets are not associated with the risk for primary open-angle glaucoma (POAG), according to a study recently published in Eye.

Akiko Hanyuda, M.D., M.P.H., from the Harvard T.H. Chan School of Public Health in Boston, and colleagues evaluated the long-term association between low-carbohydrate dietary patterns and incident POAG among 185,638 participants of three large U.S. prospective cohorts biennially (1976 to 2016, 1986 to 2016, and 1991 to 2017).

The researchers observed no association between three types of low-carbohydrate diet scores and POAG. In the highest versus lowest deciles, the multivariable-adjusted relative risks (MVRRs) for POAG were 1.13 (95 percent confidence interval [CI], 0.91 to 1.39; P for trend = 0.40) for the overall score; 1.10 (95 percent CI, 0.89 to 1.35; P for trend = 0.38) for the animal score; and 0.96 (95 percent CI, 0.79 to 1.18; P for trend = 0.88) for the vegetable score. There were no differential associations noted by intraocular pressure (P for heterogeneity ≥ 0.06). The investigators observed a suggestive inverse relationship between vegetable score and early paracentral visual field loss (highest versus lowest decile MVRR, 0.78; 95 percent CI, 0.55 to 1.10; P for trend = 0.12).

"Low-carbohydrate diets were not associated with risk of POAG," the authors write. "Our data suggested that higher consumption of fat and protein from vegetable sources substituting for carbohydrates was associated with lower risk of the POAG subtype with initial paracentral visual field loss."

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