Skip to Content

Investigational Drug May Prolong Survival in Patients With ALS

TUESDAY, Oct. 20, 2020 -- Long-term survival analysis shows that patients with earlier initiation of sodium phenylbutyrate-taurursodiol (PB-TURSO) treatment for amyotrophic lateral sclerosis (ALS) have longer median overall survival, according to a study published online Oct. 16 in Muscle & Nerve.

Noting that PB-TURSO significantly slowed functional decline in a randomized, placebo-controlled phase 2 trial in ALS (CENTAUR), Sabrina Paganoni, M.D., Ph.D., from Massachusetts General Hospital in Boston, and colleagues report on the impact of the therapy on long-term survival. In the original study, adults with ALS were randomly assigned to PB-TURSO or placebo in a 2:1 ratio. Those who completed the six-month randomized phase were eligible to receive PB-TURSO in an open-label extension. An all-cause mortality analysis was performed incorporating all randomized participants.

The researchers obtained vital status for 135 of 137 participants originally randomized. Median overall survival was 25.0 and 18.5 months among participants originally randomly assigned to PB-TURSO and placebo, respectively (hazard ratio, 0.56).

"The results presented here demonstrate a long-term survival benefit from early initiation of PB-TURSO treatment in participants with ALS, adding to the previously reported functional benefit," the authors write.

Several authors disclosed financial ties to biopharmaceutical companies, including Amylyx Pharmaceuticals, which funded the study.

Abstract/Full Text (subscription or payment may be required)

© 2021 HealthDay. All rights reserved.

Posted: October 2020

Read this next

Breast, Cervical, CRC Screening Below Healthy People 2020 Targets

FRIDAY, Jan. 15, 2021 -- Receipt of screening tests for breast, cervical, and colorectal cancers was below national Heathy People 2020 targets in 2018, according to research...

WHO Experts Finally Arrive in Wuhan for COVID-19 Investigation

THURSDAY, Jan. 14, 2021 -- After a long wait for approval from the Chinese government, a World Health Organization team of experts arrived in the city of Wuhan on Thursday to try...

Incidence of COVID-19 Increased in Children Since September

THURSDAY, Jan. 14, 2021 -- The incidence of laboratory-confirmed COVID-19 increased since September among children, adolescents, and young children, according to research...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.