Skip to Content

Hypertensive Disorders of Pregnancy Linked to Premature Mortality

TUESDAY, March 9, 2021 -- Hypertensive disorders of pregnancy (HDPs) are associated with an increased subsequent risk for premature mortality, according to a study published in the March 16 issue of the Journal of the American College of Cardiology.

Yi-Xin Wang, M.D., Ph.D., from the Harvard T.H. Chan School of Public Health in Boston, and colleagues followed 88,395 parous female nurses participating in the Nurses' Health Study II to examine whether HDPs are associated with premature mortality, while focusing on gestational hypertension and preeclampsia.

The researchers found that 2,387 women died before age 70 years, with 1,141 cancer deaths and 212 cardiovascular disease (CVD) deaths. There was an association seen for occurrence of HDPs, either gestational hypertension or preeclampsia, with premature death during follow-up, with a hazard ratio of 1.31. These associations were strongest for CVD-related mortality (hazard ratio, 2.26) on examination of specific causes of death. Regardless of the subsequent development of chronic hypertension, the association between HDPs and all-cause premature death persisted (hazard ratios, 1.20 for HDPs only and 2.02 for HDPs and subsequent chronic hypertension).

"[The authors] should be applauded on raising a biologic plausibility of the independent association of HDPs with premature all-cause mortality," write the authors of an accompanying editorial. "Contemporary management of women with HDPs will need better risk assessment tools informed by precision medicine to appropriately identify those women who are at greatest risk of premature CVD and to develop algorithms for early intervention to change the trajectory of these women."

Abstract/Full Text (subscription or payment may be required)


© 2021 HealthDay. All rights reserved.

Read this next

No Link Found for Exposure to Epidural Labor Analgesia and Autism

TUESDAY, April 20, 2021 -- Exposure to epidural labor analgesia (ELA) is not associated with offspring risk for autism spectrum disorder (ASD), according to a study published...

Gender-Affirming Hormone Therapy Tied to Systolic BP Changes

MONDAY, April 19, 2021 -- Within two to four months of starting gender-affirming hormone therapy (GAHT), transfeminine adults have lower mean systolic blood pressure and...

Bruising Clinical Decision Rule Differentiates Abuse From Nonabuse

MONDAY, April 19, 2021 -- A bruising clinical decision rule (BCDR) can differentiate abuse from nonabusive trauma in young children, according to a study published online April 14...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.