Skip to Content

HFE Hemochromatosis May Up Risk for Liver Cancer in Men

FRIDAY, Dec. 11, 2020 -- Men with hemochromatosis HFE p.C282Y homozygosity have an increased risk for incident primary hepatic malignancy and death, according to a study published in the Nov. 24 issue of the Journal of the American Medical Association.

Janice L. Atkins, Ph.D., from the University of Exeter Medical School in the United Kingdom, and colleagues conducted a cohort study involving 451,186 U.K. Biobank participants of European ancestry (aged 40 to 70 years) to examine the incidence of primary hepatic carcinoma and death for men and women with HFE p.C282Y and p.H63D genotypes.

Participants were followed for a median of 8.9 years. The researchers identified 21 incident hepatic malignancies among the 1,294 male p.C282Y homozygotes, including 10 in participants without a diagnosis of hemochromatosis at baseline. Compared with men with neither HFE variant, men who were homozygous for p.C282Y had an elevated risk for hepatic malignancies and all-cause mortality (88 deaths; hazard ratios [95 percent confidence intervals], 10.5 [6.6 to 16.7; P < 0.001] and 1.2 [1.0 to 1.5; P = 0.046], respectively). The risk for primary hepatic malignancy was 7.2 percent in lifetime projections for male p.C282Y homozygotes to age 75 years compared with 0.6 percent for men with neither variant; the corresponding risks for death were 19.5 percent (95 percent confidence interval, 15.8 to 24.0 percent) and 15.1 percent (95 percent confidence interval, 14.7 to 15.5 percent), respectively. Among 1,596 female p.C282Y homozygotes, the associations between homozygosity and hepatic malignancy and death were not statistically significant.

"The hemochromatosis faulty genes are relatively common in people with European ancestries," Atkins said in a statement. "Unfortunately, hemochromatosis is often diagnosed too late. Earlier diagnosis could prevent so much unnecessary disease."

Abstract/Full Text (subscription or payment may be required)

© 2021 HealthDay. All rights reserved.

Posted: December 2020

Read this next

Risk for Developing, Dying From Second Cancer Higher for Survivors

WEDNESDAY, Jan. 13, 2021 -- Several types of primary cancer are associated with an elevated risk for developing and dying from a subsequent primary cancer (SPC), according to a...

Overall Cancer Death Rates Decreased From 1991 to 2018

TUESDAY, Jan. 12, 2021 -- Overall cancer death rates have decreased continuously from 1991 to 2018, according to a study published online Jan. 12 in CA: A Cancer Journal for...

Affordable Care Act Reduced Income Inequality in United States

FRIDAY, Jan. 8, 2021 -- The Affordable Care Act (ACA) has reduced income inequality, with a larger decrease in states that expanded Medicaid, according to a study published in the...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.