Health Highlights: Feb. 25, 2013
Here are some of the latest health and medical news developments, compiled by the editors of HealthDay:
Asthma Drug Eases Itching from Chronic Hives: Study
The asthma drug Xolair (omalizumab) shows promise in relieving itchiness in patients with chronic hives who aren't helped by traditional antihistamine treatment.
In a phase 3 clinical trial, a monthly injection of Xolair significantly reduced hives and itchiness in these patients, according to a study published online in the The New England Journal of Medicine.
"This is the magic bullet that patients have been waiting for for the last 40 years," said study lead author Dr. Marcus Maurer, a professor of dermatology and allergy at Charit-Universitatsmedizin in Berlin, The New York Times reported.
Maurer has received consulting fees from several drug companies, including Genentech and Novartis, which paid for the study.
The study results are encouraging, according to Dr. Jonathan Bernstein, a professor of medicine and an allergy specialist at the University of Cincinnati, who was not involved in the study.
"The drug is not a cure, but it will advance our ability to manage these patients," he told The Times.
Doctor Performs Bloodless Lung Transplants
Bloodless lung transplants being performed by an American doctor hint at a possible new way of performing surgery in the future.
Dr. Scott Scheinin, of The Methodist Hospital in Houston, said a growing body of research led him to believe that blood transfusions often pose unnecessary risks and should be avoided when possible, even in complicated cases, The New York Times reported.
By choosing patients with low odds of complications, he felt he could operate almost as safely without blood transfusions as with it. Some patients refuse blood transfusions due to religious beliefs or for other reasons.
The first so-called bloodless lung transplant was conducted in 1996 at Johns Hopkins Hospital. So far, 11 so-called bloodless lung transplants have been attempted at Methodist over three years, The Times reported.
Hospital officials were initially reluctant to approve this type of procedure.
"My job is to push risk away, so I wasn't really excited about it. But the numbers were very convincing," Dr. A. Osama Gaber, the hospital's director of transplantation, told The Times.
Anemia Drug Recalled Due to Reactions Among Dialysis Patients
A voluntary recall has been issued by the makers of the anemia drug Omontys because of reports that the treatment can cause serious, and sometimes fatal, allergic reactions in some kidney dialysis patients.
Takeda Pharmaceuticals Co., of Osaka, Japan, and Palo Alto, Calif.-based Affymax Inc. said in a joint statement on their websites Sunday that all lots of the drug have been recalled and doctors should stop prescribing Omontys (peginesatide). The medication is used to treat anemia in people with chronic kidney disease.
Among the first 25,000 patients who received a first injection of Omontys, .02 percent suffered fatal allergic reactions that included anaphylaxis shock, the companies said in the statement. The reaction typically occurred within 30 minutes of the first injection of Omontys.
In a statement released Sunday, the FDA said it has received 19 reports of anaphylaxis, three resulting in death, from dialysis centers in the United States.
Some of the patients were resuscitated by doctors, the agency added.
"Due to the severity of the public health risk, we want to be certain that health care providers stop using Omontys," said Howard Sklamberg, director, Office of Compliance, FDA's Center for Drug Evaluation and Research. "Americans deserve medications that are safe, effective and of the highest quality. We are investigating the products and facilities associated with this recall and will provide updates as we learn more."
Overall, about .2 percent of dialysis patients suffered some level of allergic reaction, and a third of those were serious enough to require medical intervention and sometimes hospitalization, the companies said in their joint statement.
"Our company is working with the FDA and Affymax, and decided to voluntarily recall Omontys to put patients' safety first," said Kazumi Kobayashi, a spokesman for Takeda, Bloomberg News reported.
The U.S. Food and Drug Administration approved the treatment last March, according to Bloomberg.
New Breast Cancer Drug Approved by FDA
A new drug for late-stage breast cancer has been approved by the U.S. Food and Drug Administration.
Genentech's Kadcyla (ado-trastuzumab emtansine) is for use in patients with HER2-positive, late-stage breast cancer who were previously treated with another anti-HER2 drug called Herceptin (trastuzmab) and a class of chemotherapy drugs called taxanes, which are commonly used to treat breast cancer.
"Kadcyla is trastuzumab connected to a drug called DM1 that interferes with cancer cell growth," Dr. Richard Pazdur, director of the Office of Hematology and Oncology Products in the FDA's Center for Drug Evaluation and Research, said in an FDA news release.
"Kadcyla delivers the drug to the cancer site to shrink the tumor, slow disease progression and prolong survival. It is the fourth approved drug that targets the HER2 protein," he explained.
The FDA's approval of the drug was based on a study of 991 patients. Kadcyla carries a boxed warning that it can cause liver and heart problems and even death. It can also cause life-threatening birth defects, the agency said.
Posted: February 2013
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