Skip to Content

Greater Disability Tied to Worse COVID-19 Severity in MS Patients

FRIDAY, March 19, 2021 -- Ambulatory disability and older age are associated with worse clinical severity of COVID-19, including death, among patients with multiple sclerosis (MS), according to a study published online March 19 in JAMA Neurology.

Amber Salter, Ph.D., from the Washington University School of Medicine in St. Louis, and colleagues examined outcomes and risk factors associated with COVID-19 clinical severity in a cohort of 1,626 patients with MS. Patients were assessed after a minimum of seven days from initial symptom onset and after sufficient time had passed to observe the COVID-19 disease course through resolution of acute illness or death. Clinical outcome was classified with four levels of severity: not hospitalized, hospitalization only, admission to intensive care unit/required ventilator support, and death.

The researchers found that the overall mortality rate was 3.3 percent in the cohort. After adjustment for other risk factors, both ambulatory disability and older age were independently associated with elevated odds of all clinical severity levels compared with those not hospitalized (being nonambulatory: odds ratios: 2.8, 3.5, and 25.4 for hospitalization only, intensive care unit/required ventilator support, and death, respectively; age [every 10 years]: odds ratios, 1.3, 1.3, and 1.8, for hospitalization only, intensive care unit/required ventilator support, and death, respectively).

"Knowledge of these risk factors may enable clinicians caring for patients with MS to improve monitoring and treatment of COVID-19," the authors write.

Several authors disclosed financial ties to the biopharmaceutical industry.

Abstract/Full Text

© 2021 HealthDay. All rights reserved.

Read this next

Response to One COVID-19 Vaccine Dose Strong in Previously Infected

FRIDAY, April 16, 2021 -- For persons with a history of previous infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the neutralizing antibody titer is...

Booster Shots a Likely Reality for COVID-19-Vaccinated Americans

FRIDAY, April 16, 2021 -- Vaccinated Americans will probably need booster shots to guard against emerging coronavirus variants in the future, a White House adviser and Pfizer said...

Hemorrhagic Stroke + COVID-19 Doubles Risk for In-Hospital Mortality

FRIDAY, April 16, 2021 -- COVID-19 ups the risk for death with hemorrhagic stroke by more than twofold, according to a study published online April 14 in PLOS ONE. Vijay M....

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.