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Grass Pollen SLIT Slows Course of Allergic Rhinitis, Asthma

MONDAY, June 5, 2017 -- For patients with allergic rhinitis (AR), sublingual immunotherapy (SLIT) is associated with slower AR progression and less frequent asthma onset, according to research published online May 31 in Allergy.

Stefan Zielen, M.D., from the Goethe University Hospital in Frankfurt, Germany, and colleagues examined the real-world, long-term efficiency of grass-pollen SLIT tablets in AR in a retrospective analysis of a longitudinal prescription database. Patients with AR treated with grass pollen SLIT tablets (2,851 patients) were compared with a control group that had not received allergy immunotherapy (AIT; 71,275 patients).

The researchers found that after adjustment for covariates and relative to the pre-treatment period, AR medication use was 18.8 percent lower in the SLIT tablet group versus the non-AIT group (P < 0.001). Compared with the non-AIT group, the onset of asthma was less frequent in the SLIT tablet group (odds ratio, 0.696; P = 0.002), while time to asthma was significantly longer (hazard ratio, 0.523; P = 0.003). Compared with the non-AIT group, the SLIT group had an additional 16.7 percent decrease in asthma medication use after SLIT cessation, relative to the pre-treatment period (P = 0.004).

"Real-world treatment of AR patients with grass pollen SLIT tablets was associated with slower AR progression, less frequent asthma onset, and slower asthma progression," the authors write.

Several authors disclosed financial ties to biopharmaceutical companies, including Stallergenes Greer, which funded the study.

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Posted: June 2017