Glucocorticoid Use Tied to CVD Risk in Immune-Mediated Diseases
MONDAY, Dec. 7, 2020 -- For patients with six immune-mediated inflammatory diseases, the risk for cardiovascular disease (CVD) is increased in association with glucocorticoid dose, according to a study published online Dec. 3 in PLOS Medicine.
Mar Pujades-Rodriguez, Ph.D., from the University of Leeds in the United Kingdom, and colleagues aimed to quantify glucocorticoid dose-dependent CVD risk among 87,794 individuals with immune-mediated inflammatory diseases (giant cell arteritis and/or polymyalgia rheumatica, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, and/or vasculitis).
The researchers found that 15.3 percent of people had incident CVD. There was an increase in one-year cumulative risks for all-cause CVD from 1.4 percent in periods of nonuse to 8.9 percent for a daily prednisolone-equivalent dose of ≥25.0 mg. The corresponding five-year cumulative risks increased from 7.1 to 28 percent. Those with a daily prednisolone-equivalent dose <5.0 mg had increased all-cause CVD risk compared with periods of nonglucocorticoid use (hazard ratio, 1.74; range, 1.52 for polymyalgia and/or giant cell arteritis to 2.82 for systemic lupus erythematosus). For daily dose use <5.0 mg, the hazard ratios for type-specific cardiovascular disease were 1.69, 1.75, 1.76, 1.78, 1.32, and 1.93 for atrial fibrillation, heart failure, acute myocardial infarction, peripheral arterial disease, cerebrovascular disease, and abdominal aortic aneurysm, respectively.
"The elevated absolute risk of CVD in patients receiving high doses of glucocorticoids, of similar magnitude to that of patients with diabetes or established CVD, warrants the need to implement and evaluate intensive lifestyle modification interventions to this high-risk group," the authors write.
One author disclosed financial ties to the pharmaceutical industry; a second author disclosed ties to IQVIA.
© 2021 HealthDay. All rights reserved.
Posted: December 2020
Read this next
WEDNESDAY, Jan. 27, 2021 -- Exercise-based cardiac rehabilitation (CR) can improve cardiovascular endurance and health status among stroke survivors, according to a study...
WEDNESDAY, Jan. 27, 2021 -- Heart disease remains the leading cause of death worldwide, with 18.6 million deaths attributed to cardiovascular disease (CVD) globally in 2019,...
TUESDAY, Jan. 26, 2021 -- For patients taking angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) and hospitalized with mild-to-moderate...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.