Gilead Presents Additional Data on Efficacy of Remdesivir for COVID-19
Gilead Sciences said Friday that in a trial involving more than 1,100 patients, remdesivir was associated with improved recovery and a 62 percent reduced risk for death compared with standard care. The study also showed that 74 percent of remdesivir-treated patients recovered by day 14 of treatment compared with 59 percent of patients receiving standard care.
The findings released Friday come from a comparative analysis of 312 patients treated in the phase 3 SIMPLE-Severe study of remdesivir and 818 patients who were not in the study and received standard care. The death rate for patients treated with remdesivir was 7.6 percent at day 14 compared with 12.5 percent among patients who did not receive the drug, Gilead reported. Certain COVID-19 patients seemed to do better on the drug than others. Black patients fared especially well, the researchers found, and those younger than 65 years seemed to do better than older patients. Patients who were not on a ventilator -- breathing either room air or low-flow oxygen -- appeared to benefit more compared with those who did require a ventilator.
The results were presented at a virtual COVID-19 conference and have not been published in a peer-reviewed journal. Gilead also stressed that the findings should be considered preliminary and they require confirmation in prospective clinical trials.
Gilead said that new analyses of its "compassionate use program" showed that 83 percent of 77 children, and 92 percent of 86 pregnant and postpartum women -- all with a broad range of COVID-19 disease severity and who were treated with remdesivir -- recovered by day 28. To learn more about these groups of patients, Gilead recently announced a global, open-label phase 2/3 trial to evaluate the safety, tolerability, and action of remdesivir in patients aged 0 to 18 years and is also collaborating on a study involving pregnant women.
© 2020 HealthDay. All rights reserved.
Posted: July 2020
Further Support and Information on COVID-19
Read this next
THURSDAY, Sept. 17, 2020 -- Distribution of a COVID-19 vaccine in the United States would begin within 24 hours of its approval or emergency use authorization, and the plan is that...
THURSDAY, Sept. 17, 2020 -- There was very low influenza activity during June to August 2020 in the Southern Hemisphere, according to research published in the Sept. 18 issue of the...
THURSDAY, Sept. 17, 2020 -- Social isolation and loneliness can increase the risk for cognitive decline in seniors, according to Carla Perissinotto, M.D., geriatrician and associate...
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
- Monthly Update Archive
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.