Skip to Content

Genetics Tied to Thromboembolism Risk With Inflammatory Bowel Disease

WEDNESDAY, Nov. 18, 2020 -- Genetic variants in some patients with inflammatory bowel disease (IBD) are associated with a significantly increased risk for developing thromboembolic disease (TED), according to a study published online Oct. 21 in Gastroenterology.

Takeo Naito, Ph.D., from Cedars-Sinai Medical Center in Los Angeles, and colleagues used whole-exome sequencing and genome-wide genotyping to determine the proportion of 792 IBD patients genetically at risk for TED and investigate the effect of the genetic risk for TED in IBD.

The researchers found that 122 of 792 IBD patients (15.4 percent) were genetically at high risk for TED. Among the 715 patients with documented TED status, 8.8 percent had TED events. There was a significant association between genetic TED risk and increased TED events (odds ratio, 2.5). The investigators also observed an additive effect of monogenic and polygenic risk on TED. There was more frequent thrombosis at multiple sites seen among patients with high TED genetic risk (78 versus 42 percent; odds ratio, 3.96).

"Our results suggest that genetic traits identify approximately one in seven IBD patients who will experience 2.5-fold or greater risk for TED," the authors write.

Several authors disclosed financial ties to the pharmaceutical and biotechnology industries.

Abstract/Full Text (subscription or payment may be required)

© 2020 HealthDay. All rights reserved.

Posted: November 2020

Read this next

Review: Thromboembolism Risk High in COVID-19 Patients

TUESDAY, Dec. 1, 2020 -- The rate of thromboembolism is high in patients with COVID-19 and is associated with increased odds of mortality, according to a review published online...

Life Expectancy Has Increased for Individuals With IBD

MONDAY, Nov. 9, 2020 -- Life expectancy has increased for individuals with inflammatory bowel disease (IBD), but there is still a gap in life expectancy for those with and without...

ACG: Resilience-Based Care Coordination Program Benefits IBD

MONDAY, Nov. 2, 2020 -- The Gaining Resilience Through Transitions (GRITT) methodology, a resilience-based care coordination approach to chronic disease, can reduce health care...