Skip to Content

Exercise May Slow Cognitive Decline in Some With Early Parkinson Disease

WEDNESDAY, March 31, 2021 -- Increased levels of physical activity may have a protective effect on apolipoprotein E (APOE) ε4-related cognitive decline in early Parkinson disease (PD), according to a study published online March 31 in Neurology.

Ryul Kim, M.D., from Inha University Hospital in Incheon, South Korea, and colleagues used data from the Parkinson's Progression Markers Initiative (PPMI) cohort to examine whether greater physical activity could modify the negative association of APOE ε4 with longitudinal cognitive changes in early PD. Self-reported physical activity was initiated at two years after enrollment and was analyzed longitudinally based on assessments at years 2, 3, and 4. The Montreal Cognitive Assessment was used to measure cognitive function annually.

Data were included for 173 early PD patients (27 percent APOE ε4 carriers). The researchers found that the rate of cognitive decline was steeper with the APOE ε4 allele versus the non-APOE ε4 allele (estimate, −1.33). A significant interaction was identified between physical activity and APOE ε4, with higher physical activity related to slower APOE ε4-related cognitive decline (estimate, 0.007). Regarding changes in striatal dopamine transporter activities, there was no significant interaction between physical activity and the APOE ε4 allele.

"Additional research is needed to confirm our findings, but these results would support the use of interventions that target physical activity as a way to delay cognitive decline in people with early Parkinson's who have the APOE ε4 gene variant," one coauthor said in a statement.

Data used for this study were obtained from the PPMI database; the PPMI is funded by multiple partners, including pharmaceutical companies.

Abstract/Full Text (subscription or payment may be required)

Editorial (subscription or payment may be required)

© 2021 HealthDay. All rights reserved.

Read this next

Neighborhood Disadvantage Tied to Cognitive Decline in Older Adults

THURSDAY, April 15, 2021 -- There is a longitudinal association of neighborhood-level disadvantage with cortical thinning and cognitive decline, according to a study published...

New Criteria Aid Diagnosis of Traumatic Encephalopathy Syndrome

TUESDAY, April 13, 2021 -- With the support of experts from the Uniformed Services University, diagnostic criteria have been developed for traumatic encephalopathy syndrome (TES),...

Having Visual, Hearing Impairments Linked to Dementia in Elderly

THURSDAY, April 8, 2021 -- Coexisting visual and hearing impairments are associated with increased prevalence and incidence of dementia among older adults, according to a study...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.