Exercise May Delay Symptoms of Alzheimer's in Those at Risk
FRIDAY, Oct. 12, 2018 -- Even among individuals at high genetic risk for Alzheimer's disease, exercise may delay symptom onset, according to a study published online Sept. 25 in Alzheimer's & Dementia.
Stephan Müller, Ph.D., from the University of Tübingen in Germany, and colleagues examined 372 individuals participating in the Dominantly Inherited Alzheimer Network to evaluate the cross-sectional relationship of physical activity with cognitive performance, functional status, cognitive decline, and Alzheimer's disease biomarkers in cerebrospinal fluid.
The researchers found that mutation carriers with high physical activity showed significantly better cognitive and functional performance and significantly less Alzheimer's disease-like pathology in cerebrospinal fluid compared with individuals with low physical activity. Compared with low exercisers, mutation carriers with high physical activity scored 3.4 points better on the Mini Mental State Examination at expected symptom onset and met the diagnostic criteria of very mild dementia 15.1 years later.
"These results support a beneficial effect of physical activity on cognition and Alzheimer's disease pathology even in individuals with genetically driven autosomal dominant Alzheimer's disease," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
© 2020 HealthDay. All rights reserved.
Posted: October 2018
More News Resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
- Monthly Update Archive
Subscribe to our Newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.