Events for Living Kidney Donors Mainly Occur After Two Years
MONDAY, April 29, 2019 -- Overall, about 14.7 percent of living kidney donors have postdonation events, most of which occur more than two years after donation, according to a study published online April 12 in JAMA Network Open.
Jieming Chen, Ph.D., from the University of California in San Francisco, and colleagues conducted a cohort study on data from the transplant data set derived from 27 clinical studies from the ImmPort database. Data from 20 ImmPort clinical studies were curated, and 11,263 living donors (LDs) were studied. Data were analyzed for 9,558 living kidney donors with postdonation data.
The researchers found that 14.7 percent of LDs had postdonation events, most commonly hypertension, diabetes, proteinuria, and postoperative ileus (8.4, 2, 1.8, and 1.5 percent, respectively). Overall, 269 events occurred before two years postdonation. Most (90.2 percent) of the 1,746 events that took place two years or more after donation were nonsurgical; they tended to occur two to 40 years after donation (odds ratio, 38.3).
"Ultimately, we want to encourage and empower potential LDs, not only in seeing the benefits of living donation in saving the lives of their loved ones and strangers but also in better understanding the risks and making more informed choices when deciding to become living donors," the authors write.
Several authors disclosed financial ties to the pharmaceutical and technology industries.
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Posted: April 2019