Skip to Content

Even Moderate Caffeine Intake in Pregnancy Tied to Smaller Babies

THURSDAY, April 15, 2021 -- Even moderate daily caffeine intake during pregnancy may lead to smaller birth size, according to a study published online March 25 in JAMA Network Open.

Jessica L. Gleason, Ph.D., from the U.S. National Institutes of Health in Bethesda, Maryland, and colleagues evaluated the association between maternal caffeine intake and neonatal anthropometry by fast or slow caffeine metabolism genotype. The study was a secondary analysis of data for 2,055 nonsmoking women (mean age, 28.3 years) at low risk for fetal growth abnormalities, who had complete information on caffeine consumption, from 12 U.S. clinical sites for a cohort study that assessed fetal growth (2009 to 2013).

The researchers found that compared with the first quartile of plasma caffeine level (≤28 ng/mL), neonates of women in the fourth quartile (>659 ng/mL) had lower birth weight (β = −84.3 g) and length (β = −0.44 cm), as well as smaller head (β = −0.28 cm), arm (β = −0.25 cm), and thigh (β = −0.29 cm) circumference. Women who consumed more than 50 mg of caffeine per day (the amount in about half a cup of coffee) had neonates with lower birth weight, smaller arm and thigh circumference, and smaller anterior thigh skin fold compared with women who reported drinking no caffeinated beverages. Results were similar for fast or slow caffeine metabolism genotype.

"Findings suggest that caffeine consumption during pregnancy, even at levels much lower than the recommended 200 mg per day of caffeine, are associated with decreased fetal growth," the authors write.

Abstract/Full Text

© 2021 HealthDay. All rights reserved.

Read this next

CDC: Provisional Number of Births Decreased in 2020

WEDNESDAY, May 5, 2021 -- There was a decrease in the provisional number of births in 2020, and more New York City residents gave birth out of the city in 2020, according to two...

Topical Corticosteroid Use in Pregnancy Not Tied to SGA, LBW

WEDNESDAY, May 5, 2021 -- Topical corticosteroid use in pregnancy is not associated with increased risks for small for gestational age (SGA) or low birth weight, according to a...

Women Physicians Delay Childbearing Versus Nonphysicians

TUESDAY, May 4, 2021 -- Compared with nonphysicians, women physicians delay childbearing, with median age at first childbearing of 32 and 27 years, respectively, according to a...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.