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Early Age at Menarche Tied to Frequent Menopausal Symptoms

FRIDAY, July 31, 2020 -- Early age at menarche is a risk factor for menopausal symptoms, according to a study published online July 21 in BJOG: An International Journal of Obstetrics & Gynaecology.

Hsin-Fang Chung, Ph.D., from the University of Queensland in Brisbane, Australia, and colleagues evaluated the association between age at menarche and risk of vasomotor menopausal symptoms (VMS; hot flushes and night sweats), and the impact of midlife body mass index (BMI). Analysis included 18,555 women from the United Kingdom, United States, and Australia pooled from six cohort studies.

The researchers found that early menarche (≤11 years) was associated with an increased risk of "often" hot flushes (relative risk ratio [RRR], 1.48; 95 percent confidence interval [CI], 1.24 to 1.76) and night sweats (RRR, 1.59; 95 percent CI, 1.49 to 1.70) versus menarche at ≥14 years. Similar trends were seen with severity data, but appeared less conclusive (RRR for "severe" hot flushes: 1.16 [95 percent CI, 0.94 to 1.42]; RRR for night sweats: 1.27 [95 percent CI, 1.01 to 1.58]). Risk associated with early menarche and "often" VMS was stronger among women who were overweight or obese versus normal weight, but this trend across BMI categories was not as strong with the risk of "severe" VMS.

"These findings encourage women with early menstruation to engage in health promotion programs, especially weight management in adulthood," a coauthor said in a statement.

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Posted: July 2020