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CV Morbidity With Hysterectomy Despite Ovarian Conservation

THURSDAY, Jan. 4, 2018 -- Hysterectomy with ovarian conservation for benign indications is associated with increased risk of cardiovascular and metabolic conditions, according to a study published online Jan. 3 in Menopause.

Shannon K. Laughlin-Tommaso, M.D., M.P.H., from the Mayo Clinic in Rochester, Minn., and colleagues identified 2,094 women who underwent hysterectomy with ovarian conservation for benign indications between 1980 and 2002. Each woman was age-matched to a woman residing in the same county who had not undergone prior hysterectomy or any oophorectomy.

The researchers found that women who underwent hysterectomy experienced increased risks of de novo hyperlipidemia, hypertension, obesity, cardiac arrhythmias, and coronary artery disease over a median follow-up of 21.9 years (hazard ratios, 1.14, 1.13, 1.18, 1.17, and 1.33, respectively). The risks of congestive heart failure and coronary artery disease were increased 4.6- and 2.5-fold for women who underwent hysterectomy at age ≤35 years.

"Even with ovarian conservation, hysterectomy is associated with an increased long-term risk of cardiovascular and metabolic conditions, especially in women who undergo hysterectomy at age ≤35 years," the authors write. "If these associations are causal, alternatives to hysterectomy should be considered to treat benign gynecologic conditions."

One author disclosed financial ties to the pharmaceutical industry.

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Posted: January 2018