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Cortisol Profile Linked to Fasting Glucose in Patients With Diabetes

WEDNESDAY, July 15, 2020 -- For individuals with diabetes, changes in cortisol are positively associated with changes in fasting glucose (FG), according to a study published online July 13 in Psychoneuroendocrinology.

Jenny Pena Dias, M.P.H., Ph.D., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues examined the temporality of the association between cortisol and glucose among participants with normal fasting glucose (NFG), impaired FG, and diabetes from the Multi-Ethnic Study of Atherosclerosis.

The researchers found that in all models, among participants with diabetes, each annual percentage change increase in wake-up cortisol, total area under the curve (AUC), and overall decline slope was associated with a significant increase in FG during six years after full multivariable adjustment. Among participants with NFG at baseline, a 1 percent prior annual increase in FG was associated with a 2.8 percent lower bedtime cortisol. Among participants with diabetes, a 1 percent flatter overall decline slope was associated with a 0.19 percent increase in subsequent annual percentage change in FG over six years. There was a positive association of change in wake-up cortisol, total AUC, and overall decline slope with change in FG among participants with diabetes. Among the baseline diabetes group, baseline overall decline slope was positively associated with change in FG.

"These findings support temporality-favoring cortisol impacting changes in glucose among individuals with diabetes," the authors write.

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Posted: July 2020

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