Skip to Content

Corticosteroid Exposure Affects Bone Health in Asthma Patients

WEDNESDAY, Oct. 21, 2020 -- For patients with asthma, oral corticosteroid (OCS) and inhaled corticosteroid (ICS) use is associated with an increased risk for osteoporosis and fragility fractures (FFs), according to a study published online Oct. 20 in Thorax.

Christos V. Chalitsios, from the University of Nottingham in the United Kingdom, and colleagues conducted two nested case-control studies to examine the risk for osteoporosis and FF due to corticosteroid use in asthma. Patients with osteoporosis or FF and gender-, age-, and practice-matched controls were identified using an asthma cohort.

The researchers observed a dose-response relationship between both cumulative dose and number of OCS/ICS prescriptions within the previous year with osteoporosis or FF risk. People receiving more OCS prescriptions (≥9 versus 0) had a 4.50 and 2.16 increased risk for osteoporosis and FF, respectively, after adjustment for confounders. The odds ratios were 1.60 and 1.31 for osteoporosis and FF, respectively, for ICS (≥11 versus 0). A similar impact was seen for the cumulative dose, with greater risk for those receiving more OCS or ICS. For osteoporosis and FF, the prevalence of patients taking ≥9 OCS and at least one bisphosphonate prescription was 50.6 and 48.4 percent, respectively.

"The use of OCS and ICS should be kept to the minimum necessary to treat symptoms and should be stepped down if symptoms and exacerbations are well managed," the authors write.

Abstract/Full Text

© 2020 HealthDay. All rights reserved.

Posted: October 2020

Read this next

American College of Allergy, Asthma & Immunology, Nov. 12-16

The annual meeting of the American College of Allergy, Asthma & Immunology was held virtually this year from Nov. 12 to 16 and attracted participants from around the world,...

Hormonal Contraceptives Linked to Decline in Asthma Exacerbation

WEDNESDAY, Nov. 25, 2020 -- Previous and current use of any and combined hormonal contraceptives is associated with a reduction in the risk for severe asthma exacerbation,...

Vegans Have Increased Risk for Total, Main-Site Fractures

MONDAY, Nov. 23, 2020 -- Vegans have increased risks for total fractures and some site-specific fractures compared with meat eaters, according to a study published online Nov. 23...