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What Will Convince Americans to Get a COVID-19 Vaccine?

TUESDAY, Oct. 20, 2020 -- Promoting any emerging COVID-19 vaccine to a skeptical public could be tough.

But a new survey finds vaccine uptake might rise if the shot is promoted by medical experts, not politicians, and if it's been proven safe and effective through a rigorous approval process.

A vaccine shown to be highly effective in clinical trials with lasting protection and rare major side effects will command more public respect, particularly if major public health organizations endorse it, researchers found.

There won't be as many takers for a vaccine that meets minimum U.S. Food and Drug Administration standards, is approved under emergency use protocols, and is endorsed by politicians rather than medical experts, according to findings published Oct. 20 in JAMA Network Open.

These results show that efforts to develop and promote a COVID-19 vaccine need to be depoliticized, said senior researcher Douglas Kriner, a professor of government at Cornell University.

"The rollout of the vaccine and the public health effort to communicate to people the importance of doing this, that it's safe and effective and trying to encourage people to vaccinate, should really be left to the public health professionals," Kriner said.

An endorsement from either U.S. presidential candidate would do little to promote the vaccine, while a nod from either the World Health Organization or the U.S. Centers for Disease Control and Prevention would carry great weight, the survey showed.

"It's hard to imagine politicians not wanting to wade in on this, rather than simply deferring to the medical experts, but the more they engage, the more problems that might cause," Kriner said.

Further, the speed at which the vaccine is being developed and tested could well complicate efforts to have it widely accepted, noted Dr. William Schaffner, a professor of infectious disease at Vanderbilt University Medical Center in Nashville, Tenn.

"The very name, Operation Warp Speed, works against us," he said. "The average citizen who hears this thinks that we're cutting corners, and they want nothing to do with that."

An approved COVID-19 shot is still months away, but the CDC already is preparing for the widespread rollout of any vaccine that receives FDA approval.

At least 70% of adults in an area need to take a COVID-19 vaccine to achieve herd immunity, according to researchers' estimates.

But up to now, surveys have varied widely on whether people plan to get a COVID shot once one is available.

Kriner and his team decided to take a deeper look into the specific factors that will influence public acceptance.

They surveyed nearly 2,000 adults across the United States, asking about an array of factors that could potentially influence vaccine acceptance -- effectiveness, how long the protection will last, risk of side effects, the type of approval, where the vaccine is developed, and the endorsements it gets from major figures and institutions.

Effectiveness will be the single most important factor in promoting the vaccine, researchers found.

People will be most strongly motivated to take a vaccine that is 70% to 90% effective, as opposed to one that is only 50% effective, the survey results show.

"One thing that might be disturbing here for us is that 50% efficacy is the FDA's minimum threshold, and willingness to take the vaccine was relatively low at that level," Kriner said.

The public also will be less inclined to accept a COVID vaccine approved under an FDA emergency use authorization, which shortcuts the agency's usual approval process, the survey found.

"It's justifiable that we're using an incredible number of resources to increase the speed at which we have a vaccine made available, but at the same time we have to not compromise on safety," said Dr. Douglas Opel, director of clinical ethics at Seattle Children's Research Institute. He co-wrote an editorial that accompanied the survey findings.

"This process of making a vaccine available through an emergency use authorization is at this juncture of speed and safety, and this study found a vaccine made available through that expedited mechanism would negatively impact willingness to accept it, so that was concerning," Opel said.

Endorsements from politicians didn't matter much to survey respondents.

"The lowest level of support or willingness to vaccinate is if the vaccine was endorsed and recommended by President Trump," Kriner said. "An endorsement from Vice President Biden doesn't fare a whole lot better."

Study respondents also were much less willing to receive a vaccine developed in China than one developed in the United States or the United Kingdom.

Opel said the detailed nature of this survey will be "really helpful" in promoting confidence and uptake of the vaccine once it rolls out.

Any COVID vaccine will best be promoted by family doctors, backed up by transparent and compelling data and endorsements from respected medical leaders and institutions, Schaffner said.

People get routine vaccinations based on their doctor's strong recommendation above any other factor, he noted.

"I would build on that, and the vast amount of trust that still exists between the individual practitioner and their patients," Schaffner said.

But doctors and officials also need to communicate that a vaccine will not be the cure-all that allows everyone to return to their pre-COVID lives, he added.

"If it's 70% effective, which would be pretty good, that means that out of every 10 people vaccinated, seven will be protected, but three -- and we don't know who those three are -- probably have no or very little protection," Schaffner said. "Just because you get vaccinated does not mean you can throw away your mask. You're going to have to keep masking, social distancing, avoiding large groups for long periods of time."

That's something the public doesn't seem to fully grasp.

"Whenever I mention that, everybody gets grumpy because they think once I get that needle in my arm, I'm now wearing a suit of armor," Schaffner said. "I can go out and do anything I want again. I can go back to the old normal. Incorrect. We haven't been preparing the public for that."

© 2020 HealthDay. All rights reserved.

Posted: October 2020

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