Skip to Content

Continuing Treatment Not Beneficial After Five Years of Bisphosphonates

FRIDAY, Dec. 11, 2020 -- For women who have received five years of bisphosphonate therapy, hip fracture risk does not differ with continuing treatment for an additional five years versus discontinuing treatment, according to a study published online Dec. 7 in JAMA Network Open.

Monika A. Izano, Ph.D., from Kaiser Permanente Northern California in Oakland, and colleagues examined the correlation of discontinuing bisphosphonates at study entry, discontinuing at two years, and continuing for five additional years with hip fracture risk among 29,685 women who had completed five years of bisphosphonate treatment at study entry.

The researchers identified 507 incident hip fractures. There were no differences in the cumulative incidence of hip fracture if women remained on therapy for two additional years or if they continued therapy for five additional years compared with bisphosphonate discontinuation at study entry (five-year risk difference, −2.2 [95 percent confidence interval, −20.3 to 15.9] per 1,000 individuals and 3.8 [95 percent confidence interval, −7.4 to 15.0] per 1,000 individuals, respectively). If women discontinued after two additional years, the interim hip fracture risk appeared lower (three-year risk difference, 2.8 [95 percent confidence interval, 1.3 to 4.3] per 1,000 individuals; four-year risk difference, 9.3 per 1,000 individuals [95 percent confidence interval, 6.3 to 12.3]).

"A potential benefit was suggested from continuing an additional two years, but the association of discontinuation at two years and other points with fracture risk should be further studied in randomized clinical trials," the authors write.

One author disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text

© 2021 HealthDay. All rights reserved.

Posted: December 2020

Read this next

Denosumab Studied for Prosthesis-Related Osteolysis

THURSDAY, Jan. 21, 2021 -- For patients with symptomatic, radiographically confirmed osteolysis undergoing revision total hip arthroplasty surgery, a single dose of denosumab...

Post-Hip Fracture Mortality Higher in Patients Living Alone

FRIDAY, Jan. 8, 2021 -- Hip fracture patients who live alone have higher mortality than those living with a partner, according to a study published online Jan. 6 in the Journal of...

Rehospitalization Down With Remote Monitoring After Arthroplasty

THURSDAY, Jan. 7, 2021 -- For patients undergoing hip or knee arthroplasty, a remote monitoring program does not affect the rate of discharge to home but does result in a...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.