Skip to Content

Cocaine Use, HIV Affect Coronary Plaque Morphology

TUESDAY, Feb. 23, 2021 -- Cocaine use and HIV infection are associated with radiomic features quantified for coronary plaque morphology, according to a study published online Feb. 16 in Radiology.

Márton Kolossváry, M.D., Ph.D., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues examined the contribution of different cardiovascular risk factors to changes in coronary plaque morphologic features. Individuals with or without HIV infection and cocaine use and without cardiovascular symptoms underwent coronary computed tomography (CT) angiography between May 2004 and August 2015. The effects of cocaine use, HIV infection, and atherosclerotic cardiovascular disease (ASCVD) risk on the temporal changes (mean, 4.0 years) in coronary artery disease structure were analyzed for 300 participants.

For each plaque, 1,276 radiomic features were quantified. The researchers found that cocaine use, HIV infection, and elevated ASCVD risk were significantly associated with 23.7, 1.3, and 8.2 percent of the radiomic features (303, 17, and 104 of 1,276, respectively). There was no overlap noted for parameters associated with elevated ASCVD risk or cocaine use and HIV infection. Thirteen clusters were identified among the 409 parameters, of which eight were affected only by cocaine use and three were affected only by ASCVD risk.

"Our results also suggest that interpatient variability of coronary artery disease on coronary CT angiography, regardless of conventional cardiovascular risk, is caused by environmental factors -- not just genetic factors," the authors write. "These include nontraditional risk factors, such as HIV infection and cocaine use."

One author disclosed financial ties to Radiomics Image Analysis.

Abstract/Full Text

Editorial (subscription or payment may be required)

© 2021 HealthDay. All rights reserved.

Posted: February 2021

Read this next

U.S. Patterns for Recurrent Coronary Heart Disease Examined

FRIDAY, Feb. 26, 2021 -- From 2008 to 2017, the rates of recurrent myocardial infarction (MI), recurrent coronary heart disease (CHD) events, heart failure hospitalization, and...

Among Blacks, Late-Stage HIV Diagnosis Varies by Rurality

FRIDAY, Feb. 19, 2021 -- The percentage of Black people with late-stage HIV diagnosis varies according to population area of residence and is higher in rural than urban and...

Advanced Practice Providers Use ED Resources Similarly to Physicians

WEDNESDAY, Feb 10, 2021 -- Use of diagnostic resources and admissions in emergency department patients with chest or abdominal pain are similar regardless of treatment by an...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.