Childhood-Onset IBD Ups Risk for Psychiatric Morbidity
TUESDAY, Aug. 20, 2019 -- Childhood-onset inflammatory bowel disease (IBD) is associated with an increased risk for psychiatric morbidity, including suicide attempt, according to a study published online Aug. 19 in JAMA Pediatrics.
Agnieszka Butwicka, M.D., Ph.D., from the Karolinska Institutet in Stockholm, and colleagues examined the risk for psychiatric morbidity in individuals with childhood-onset IBD in a population-based cohort study. Data were included for 6,464 individuals with a diagnosis of childhood-onset IBD who were compared to 323,200 matched reference individuals from the general population and 6,999 siblings of patients with IBD.
The researchers found that 17.3 percent of individuals with IBD received a diagnosis of any psychiatric disorder during a median follow-up of nine years compared with 11.8 percent in the general population (incidence rate, 17.1 versus 11.2 per 1,000 person-years), corresponding to a hazard ratio of 1.6 and representing one additional case of psychiatric disorder per 170 person-years. IBD correlated significantly with suicide attempt, mood disorders, anxiety disorders, eating disorders, personality disorders, attention-deficit/hyperactivity disorder, and autism spectrum disorders (hazard ratios, 1.4, 1.6, 1.9, 1.6, 1.4, 1.2, and 1.4, respectively). Boys and girls had similar results. In the first year of follow-up, the hazard ratios for any psychiatric disorder were highest, but they remained significantly elevated after more than five years. In between-sibling comparisons, the results were largely confirmed.
"Long-term psychological support should therefore be considered for patients with childhood-onset IBD," the authors write.
Several authors disclosed financial ties to the pharmaceutical industry.
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Posted: August 2019