Chemo, Immunotherapy Feasible in Metastatic Bladder Cancer
WEDNESDAY, April 11, 2018 -- Gemcitabine and cisplatin (GC) plus ipilimumab is associated with a 69 percent objective response rate and 61 percent one-year overall survival for patients with metastatic urothelial cancer, according to a study published in the May issue of European Urology.
Matthew D. Galsky, M.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues conducted a multicenter phase 2 study enrolling 36 chemotherapy-naive patients with metastatic urothelial cancer. All patients underwent peripheral blood flow cytometry and 28 patients underwent whole exome sequencing of archival tumor tissue. Patients received two cycles of GC followed by four cycles of GC plus ipilimumab.
The researchers found that 81 percent of patients had grade ≥3 adverse events, most of which were hematologic. There was a 69 percent objective response rate; one-year overall survival was 61 percent. After GC alone, there were no significant changes in the composition and frequency of circulating immune cells. With the addition of ipilimumab, there was a significant expansion of circulating CD4 cells, which correlated with improved survival. A significantly higher response rate was seen in patients with deleterious somatic DNA damage response mutations
"Because chemotherapy and immunotherapy are the two pillars of treatment for metastatic bladder cancer, we sought to better understand how these treatments might be best given together," Galsky said in a statement. "Already the results of this trial have inspired the creation of two more trials that seek to better the treatment of bladder cancer patients by combining chemotherapy with immunotherapy."
The study was funded by Bristol-Myers Squibb.
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Posted: April 2018