Skip to Content

Cardiorespiratory Fitness Reduced With Prolonged ADT in Prostate Cancer

MONDAY, Nov. 30, 2020 -- For patients with localized high-risk prostate cancer (PC), prolonged androgen deprivation therapy (ADT) is associated with reduced cardiorespiratory fitness (CRF) and increased cardiovascular (CV) mortality, according to a study published in the Nov. 1 issue of JACC: CardioOncology.

Jingyi Gong, M.D., from Brigham and Women's Hospital in Boston, and colleagues compared CRF and CV mortality among patients with PC with and without ADT exposure. Data were included for 616 patients who underwent exercise treadmill testing (ETT) a median of 4.8 years after PC diagnosis; 150 (24.3 percent) received ADT prior to ETT, including 99 and 51 with short-term and prolonged exposure, respectively.

The researchers found that in adjusted analyses, prolonged ADT correlated with reduced CRF (odds ratio, 2.71; 95 percent confidence interval [CI], 1.31 to 5.61; P = 0.007) and increased CV mortality (hazard ratio, 3.87; 95 percent CI, 1.16 to 12.96; P = 0.028). In adjusted Cox regression models, the correlation between short-term ADT exposure and reduced CRF was of borderline significance (odds ratio, 1.71; 95 percent CI, 1.00 to 2.94; P = 0.052), while no correlation was observed with CV mortality (hazard ratio, 1.60; 95 percent CI, 0.51 to 5.01; P = 0.420).

"These findings emphasize the need to consider CV surveillance/risk modification during and after ADT exposure," a coauthor said in a statement.

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text

Editorial

© 2021 HealthDay. All rights reserved.

Posted: November 2020

Read this next

Mediterranean Diet Tied to Lower Risk for Prostate Cancer Progression

THURSDAY, Jan. 21, 2021 -- For men with newly diagnosed prostate cancer on active surveillance, adherence to the Mediterranean diet (MedD) is associated with a lower risk for...

Default Opt-Out of Cardiac Rehabilitation Increases Referrals

TUESDAY, Jan. 19, 2021 -- For inpatients with ischemic heart disease, redesign of decision pathways from default opt-in to opt-out of cardiac rehabilitation (CR) results in a...

Drop in ED Visits for Cardiac Conditions Tied to Later Cardiac Deaths

THURSDAY, Jan. 14, 2021 -- Reduced emergency department visits for suspected cardiac disease during the COVID-19 pandemic peak in England are associated with a time-lagged...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.