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Bismuth-Based Quad Tx Doesn't Top Levofloxacin Triple Tx

FRIDAY, July 14, 2017 -- For patients with Helicobacter pylori infection, the addition of bismuth subcitrate to levofloxacin-based triple therapy is not associated with increased effectiveness, although there are no more side effects, according to a study published online June 23 in the Journal of Digestive Diseases.

Tzung-Shiun Wu, from the Kaohsiung Medical University Hospital in Taiwan, and colleagues conducted a prospective study involving 67 patients infected with H. pylori. Patients were randomized to receive levofloxacin plus bismuth-based quadruple therapy (RBAL) for 10 days (33 patients) or levofloxacin-based triple therapy (RAL) for 10 days (34 patients). The response was assessed using endoscopy performed four to eight weeks after eradication.

The researchers found that both groups showed similar eradication rates (84.8 and 67.6 percent for RBAL and RAL, respectively; P = 0.373) in intention-to-treat analysis. There was no significant difference in compliance (P = 1.031); adverse events were also similar between the groups. Most cases of eradication failure were levofloxacin resistant.

"Levofloxacin-resistant rate may be a more important role when choosing second-line therapy," the authors write.

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Posted: July 2017