Skip to Content

Autistic Traits ID'd in Carriers of CNVs Linked to Autism

MONDAY, Jan. 4, 2021 -- Many carriers of copy number variants (CNVs) associated with autism meet clinical cutoffs for autistic traits, according to a study published online Jan. 1 in the American Journal of Psychiatry.

Samuel J.R.A. Chawner, Ph.D., from Cardiff University in the United Kingdom, and colleagues conducted an international study involving 547 individuals who were ascertained based on a genetic diagnosis of a rare CNV associated with a high risk for autism and 2,027 individuals with autism of heterogeneous etiology.

The researchers found that autism symptom severity, autism subdomain profile, and IQ profile differed for the four genetic variant groups. However, in individual genetic variant groups, substantial variability was observed in phenotypic outcome (74 to 97 percent of the variance), while variability between the groups was low (1 to 21 percent). A range of profile differences was identified upon comparison of CNV carriers who met autism criteria with individuals with heterogeneous autism. Fifty-four percent of individuals with one of the four CNVs who did not meet full autism diagnostic criteria had elevated levels of autistic traits when clinical cutoff scores were applied.

"More than half of those with these genetic conditions had significant symptoms associated with it -- such as social and communication difficulties or repetitive behaviors," Chawner said in a statement. "There is a danger that being too prescriptive with how autism is diagnosed will result in these individuals slipping through the net and being denied important services."

Several authors disclosed financial ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

© 2021 HealthDay. All rights reserved.

Posted: January 2021

Read this next

Cancer Screening, Diagnoses Down During Early Pandemic

FRIDAY, Jan. 22, 2021 -- There was a significant decrease in the number of patients undergoing screening tests for cancer and in the number of resulting diagnoses of cancerous and...

Non-Hispanic Blacks Underrepresented on Transplant Wait List

THURSDAY, Jan. 21, 2021 -- Non-Hispanic Black patients are disproportionately left off liver transplant wait lists, according to a study published online Jan. 11 in the Journal of...

Patient Age Linked to Choice of Telepsychiatry Visit Type

THURSDAY, Jan. 21, 2021 -- Patient age is associated with the choice of telepsychiatry visit type, and many patients report being likely to continue with telepsychiatry even after...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.