Skip to Content

ATA Issues Guidelines for Managing Anaplastic Thyroid Cancer

FRIDAY, April 16, 2021 -- In new guidelines issued by the American Thyroid Association and published in the March issue of Thyroid, recommendations are presented for the diagnosis, evaluation, and treatment of anaplastic thyroid cancer (ATC).

Keith C. Bible, M.D., Ph.D., from the Mayo Clinic in Rochester, Minnesota, and colleagues reviewed the relevant literature to develop guidelines relating to the diagnosis and management of ATC.

The guidelines include rapidly and definitively establishing a diagnosis, with early assessment of tumor mutations key to expanding therapeutic options. Early multidisciplinary involvement of surgeons, radiation and medical oncologists, endocrinologists, and palliative care teams should be coordinated to arrive at options for best care. To classify the disease as stage IVA, IVB, or IVC, staging with imaging is required; the extent of local invasion should also be assessed to assist with surgical decision-making. Patient counseling must be provided to establish individualized patient goals of care and should involve the patient and supportive individuals/family members. Surgical options should be evaluated, with complete resection and prompt transition to adjuvant definitive-intention therapy the primary goals for patients with stages IVA and IVB ATC. The limited benefit of surgery in IVC ATC should be tempered in consideration of other palliative approaches. Nonsurgical approaches should also be considered within the context of patient goals of care and willingness to accept anticipated toxicities. Hospice should be presented among care options given the historically dire prognosis of ATC, especially stage IVC.

"Despite significant advances in the diagnosis and treatment of patients with ATC, there remains a critical need for more effective therapies," the authors write.

Abstract/Full Text

© 2021 HealthDay. All rights reserved.

Read this next

AI System Can Predict Deterioration in COVID-19 Patients in ED

THURSDAY, May 13, 2021 -- An artificial intelligence (AI) system can predict deterioration of COVID-19 patients in the emergency department, according to a study published online...

Noninvasive Markers Aid Risk Assessment of Prostate Cancer

THURSDAY, May 13, 2021 -- Integration of data from multiple, noninvasive biomarkers can improve risk assessment of patients with a clinical suspicion of prostate cancer prior to...

ACC: Neighborhood Tied to Death Risk After Surviving a Heart Attack

THURSDAY, May 13, 2021 -- Neighborhood disadvantage is independently associated with increased mortality after myocardial infarction (MI), according to a study presented at the...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.