Skip to Content

Assessing HDL Anti-Inflammatory Capacity May Aid CV Risk Prediction

WEDNESDAY, April 28, 2021 -- Measuring high-density lipoprotein (HDL) anti-inflammatory capacity may improve cardiovascular disease risk assessment, according to a study published online April 12 in Circulation.

Congzhuo Jia, M.D., from University of Groningen in the Netherlands, and colleagues assessed whether HDL anti-inflammatory capacity was prospectively associated with first cardiovascular events in the general population. The analysis included 340 cases experiencing a first cardiovascular event and followed for a median of 10.5 years as well as matched controls with baseline samples.

The researchers found that HDL anti-inflammatory capacity was not associated with HDL cholesterol or high-sensitivity C-reactive protein. HDL anti-inflammatory capacity was significantly lower in cases compared with controls (31.6 versus 27.0 percent) and was inversely associated with incident cardiovascular disease in a fully adjusted model (odds ratio [OR] per one standard deviation [SD], 0.74). Similar associations were seen for all individual components of the cardiovascular disease end point. There was no association observed between HDL anti-inflammatory capacity and cholesterol efflux capacity. When efflux and anti-inflammatory capacity were combined in one adjusted model, both were significantly and independently associated with incident cardiovascular disease (efflux: OR per one SD, 0.74; anti-inflammatory capacity: OR per one SD, 0.66). Risk prediction using the Framingham risk score was improved by adding HDL anti-inflammatory capacity.

"The HDL anti-inflammatory capacity could represent a novel pharmacological intervention target for improving cardiovascular disease risk," the authors write.

One author reported ties to the pharmaceutical industry.

Abstract/Full Text (subscription or payment may be required)

© 2021 HealthDay. All rights reserved.

Read this next

Half of Cardiology Trainees Comfortable With Telemedicine Use

WEDNESDAY, May 12, 2021 -- About half of trainee cardiologists report being comfortable with use of telemedicine, and most express the need for telemedicine-specific training,...

Longitudinal CV Risk Inversely Linked to Cognitive Performance

MONDAY, May 10, 2021 -- Elevated systolic blood pressure, high serum total cholesterol, and obesity from childhood through adulthood are inversely associated with midlife...

Low Bone Mineral Density Prognostic for Atherosclerotic CVD

FRIDAY, May 7, 2021 -- Bone mineral density (BMD) has independent prognostic value for predicting atherosclerotic cardiovascular disease (ASCVD) in women, according to a study...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of in your inbox.