Skip to Content

ASN: Finerenone May Slow Progression in CKD With T2DM

MONDAY, Oct. 26, 2020 -- Finerenone results in a lower risk for chronic kidney disease (CKD) progression in patients with CKD and type 2 diabetes, according to a study published online Oct. 23 in the New England Journal of Medicine to coincide with Kidney Week, the annual meeting of the American Society of Nephrology, held virtually from Oct. 22 to 25.

George L. Bakris, M.D., from the University of Chicago, and colleagues conducted a double-blind trial involving 5,734 patients with CKD and type 2 diabetes who were randomly assigned to receive either finerenone or placebo in a 1:1 ratio. All patients were treated with a renin-angiotensin system blockade that had been adjusted (before randomization) to the maximum dose that did not cause unacceptable side effects.

The researchers found that a primary outcome event (kidney failure, sustained decrease of at least 40 percent in the estimated glomerular filtration rate from baseline, or death from renal causes) occurred in 17.8 and 21.1 percent of patients in the finerenone and placebo groups, respectively (hazard ratio, 0.82) during a median follow-up of 2.6 years. A key secondary outcome event (death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) occurred in 13.0 and 14.8 percent of the finerenone and placebo groups, respectively (hazard ratio, 0.86). The groups had a similar frequency of adverse events overall.

"These results suggest that in patients with CKD and type 2 diabetes, finerenone may be an effective treatment for kidney and cardiovascular protection," the authors write. "The observed benefits of finerenone were clinically significant and were obtained on a background of guideline-directed therapy."

The study was funded by Bayer, the manufacturer of finerenone.

Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
More Information

© 2021 HealthDay. All rights reserved.

Posted: October 2020

Read this next

Hospitalizations for Diabetic Foot Ulcer Up in Australia

TUESDAY, Jan. 26, 2021 -- Hospitalizations for diabetes-related foot ulcers (DFUs) are increasing, according to a study published online Jan. 13 in Diabetes Care. Emma J....

Metabolic Surgery Effective for Long-Term T2DM Control

MONDAY, Jan. 25, 2021 -- For individuals with type 2 diabetes, metabolic surgery is more effective than medical therapy for long-term control, according to a study published in...

Renal Insufficiency May Worsen Multiple Myeloma Outcomes

FRIDAY, Jan. 22, 2021 -- For patients with multiple myeloma (MM), those with renal insufficiency (RI) have an increased risk for disease progression or death, according to a...

More News Resources

Subscribe to our Newsletter

Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.