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Alcohol Intake Inversely Linked to Fecundability

WEDNESDAY, June 9, 2021 -- Alcohol intake is inversely associated with fecundability, according to a study published online June 8 in Human Reproduction.

Mohammad Yaser Anwar, M.P.H., M.D., Ph.D., from the University of Louisville School of Public Health and Information Sciences in Kentucky, and colleagues recruited and followed 413 participants in the Mount Sinai Study of Women Office Workers between 1990 and 1994, who reported their alcohol intake for a maximum of 19 months of follow-up.

The researchers found that moderate (three to six drinks/week) and heavy drinking (more than six drinks/week) in the luteal phase were associated with a reduction in fecundability compared with nondrinkers (fecundability odds ratios [FORs], 0.56 and 0.51, respectively). For the follicular phase, reduced fecundability was seen in association with heavy drinking in the ovulatory subphase compared with nondrinkers (FOR, 0.39). Heavy drinking was associated with a reduction in fecundability for the preovulatory subphase (FOR, 0.54), but the correlation was inconsistent when subjected to sensitivity tests. Each extra day of binge drinking correlated with reductions in fecundability in the luteal and ovulatory subphases (FORs, 0.81 and 0.59, respectively), but no correlation was seen in the preovulatory subphase. No meaningful between-beverage differences in fecundability were seen in any of the menstrual phases.

"During the luteal phase, which is the last two weeks of the menstrual cycle before bleeding would start and when the process of implantation occurs, not only heavy drinking but also moderate drinking was significantly associated with a reduced probability of conception," a coauthor said in statement.

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