Alcohol Induced DNA Repair Genes Prognostic in Gastric Cancer
THURSDAY, Jan. 18, 2018 -- For patients with gastric cancer (GC), myeloperoxidase (MPO), transcription factor IIB-related factor 1 (BRF1), and breast cancer susceptibility genes 1 and 2 (BRCA1/2) induced by alcohol have prognostic value, according to a study published in the February issue of The American Journal of Pathology.
Yiyin Zhang, from the First Affiliated Hospital of Anhui Medical University in Hefei, China, and colleagues examined the prognostic value of MPO, BRF1, BRCA1, and BRCA2 upon alcohol induction using human GC biopsies.
The researchers found that GC patients with hazardous or harmful alcohol consumption habits more often had high expression of BRF1 (P = 0.010) and positive cell infiltration of MPO (P = 0.004) in tumor tissues, as well as positive expression of BRCA1 in para-tumor tissues (P < 0.001). For disease-free survival, BRF1 (P = 0.021), BRCA2 (P < 0.001), and MPO (P = 0.039) were independent prognostic factors. For overall survival, BRCA1 (P = 0.005) and BRCA2 (P < 0.001) were also identified as independent prognostic factors. In GC patients who underwent platinum-based adjuvant chemotherapy, BRCA2 was an independent unfavorable prognostic factor for disease-free and overall survival (P < 0.001).
"Our results suggest that BRF1, BRCA1/2, and MPO, which are DNA repair-related biomarkers induced by alcohol, have prognostic value in GC patients," the authors write. "These innovative findings are of great significance, and additional larger clinical studies are warranted."
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Posted: January 2018